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SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire

The risk of viral infection during pregnancy is well-documented; however, the intervention modalities that in practice enable maternal-fetal protection are restricted by limited understanding. This becomes all the more challenging during pandemics. During many different epidemic and pandemic viral o...

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Autores principales: Rajput, Roopali, Sharma, Jitender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594046/
https://www.ncbi.nlm.nih.gov/pubmed/34816202
http://dx.doi.org/10.3389/fgwh.2021.647836
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author Rajput, Roopali
Sharma, Jitender
author_facet Rajput, Roopali
Sharma, Jitender
author_sort Rajput, Roopali
collection PubMed
description The risk of viral infection during pregnancy is well-documented; however, the intervention modalities that in practice enable maternal-fetal protection are restricted by limited understanding. This becomes all the more challenging during pandemics. During many different epidemic and pandemic viral outbreaks, worse outcomes (fetal abnormalities, mortality, preterm labor, etc.) seem to affect pregnant women than what has been evident when compared to non-pregnant women. The condition of pregnancy, which is widely understood as “immunosuppressed,” needs to be re-understood in terms of the way the immune system works during such a state. The immune system gets transformed to accommodate and facilitate fetal growth. The interference of such supportive conversion by viral infection and the risk of co-infection lead to adverse fetal outcomes. Hence, it is crucial to understand the risk and impact of potent viral infections likely to be encountered during pregnancy. In the present article, we review the effects imposed by previously established and recently emerging/re-emerging viral infections on maternal and fetal health. Such understanding is important in devising strategies for better preparedness and knowing the treatment options available to mitigate the relevant adverse outcomes.
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spelling pubmed-85940462021-11-22 SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire Rajput, Roopali Sharma, Jitender Front Glob Womens Health Global Women's Health The risk of viral infection during pregnancy is well-documented; however, the intervention modalities that in practice enable maternal-fetal protection are restricted by limited understanding. This becomes all the more challenging during pandemics. During many different epidemic and pandemic viral outbreaks, worse outcomes (fetal abnormalities, mortality, preterm labor, etc.) seem to affect pregnant women than what has been evident when compared to non-pregnant women. The condition of pregnancy, which is widely understood as “immunosuppressed,” needs to be re-understood in terms of the way the immune system works during such a state. The immune system gets transformed to accommodate and facilitate fetal growth. The interference of such supportive conversion by viral infection and the risk of co-infection lead to adverse fetal outcomes. Hence, it is crucial to understand the risk and impact of potent viral infections likely to be encountered during pregnancy. In the present article, we review the effects imposed by previously established and recently emerging/re-emerging viral infections on maternal and fetal health. Such understanding is important in devising strategies for better preparedness and knowing the treatment options available to mitigate the relevant adverse outcomes. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8594046/ /pubmed/34816202 http://dx.doi.org/10.3389/fgwh.2021.647836 Text en Copyright © 2021 Rajput and Sharma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Global Women's Health
Rajput, Roopali
Sharma, Jitender
SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title_full SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title_fullStr SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title_full_unstemmed SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title_short SARS-CoV-2 in Pregnancy: Fitting Into the Existing Viral Repertoire
title_sort sars-cov-2 in pregnancy: fitting into the existing viral repertoire
topic Global Women's Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594046/
https://www.ncbi.nlm.nih.gov/pubmed/34816202
http://dx.doi.org/10.3389/fgwh.2021.647836
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