Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

BACKGROUND: Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be a factor influencing TFE3 breaks, and the topoisomerase II (TOP2) poison is...

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Detalles Bibliográficos
Autores principales: Shi, Qiancheng, Liu, Ning, Yang, Lei, Chen, Yi, Lu, Yanwen, Guo, Hongqian, Han, Xiaodong, Li, Dongmei, Gan, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594210/
https://www.ncbi.nlm.nih.gov/pubmed/34784933
http://dx.doi.org/10.1186/s12964-021-00790-3

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