Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas

BACKGROUND: Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been proposed as a common hallmark of TH and TC. BH3 profiling can...

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Detalles Bibliográficos
Autores principales: Müller, Denise, Mazzeo, Paolo, Koch, Raphael, Bösherz, Mark-Sebastian, Welter, Stefan, von Hammerstein-Equord, Alexander, Hinterthaner, Marc, Cordes, Lucia, Belharazem, Djeda, Marx, Alexander, Ströbel, Philipp, Küffer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594228/
https://www.ncbi.nlm.nih.gov/pubmed/34781947
http://dx.doi.org/10.1186/s12916-021-02158-3

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