Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes

BACKGROUND: Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into bioactive IL-1β and IL-18, respectively. GSDMD amino-terminal fragmen...

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Detalles Bibliográficos
Autores principales: Yang, Tong, Sun, Kai, Wang, Chun, Swarnkar, Gaurav, Quan, Songtao, Kress, Dustin, Xiao, Jianqiu, Alippe, Yael, Zheng, Hongjun, Brophy, Robert H, Hao, Dingjun, McAlinden, Audrey, Abu-Amer, Yousef, Shen, Jie, Mbalaviele, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594229/
https://www.ncbi.nlm.nih.gov/pubmed/34784954
http://dx.doi.org/10.1186/s13075-021-02668-8

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