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Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series

Rapid emergence of syphilis and oral sexual behaviors has focused attention on oral syphilis, and published reports of cases with oral syphilis have increased in the recent decades. We performed a systematic literature review by searching articles from PubMed, EMBSE, and Google Scholar, looking for...

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Autores principales: Zhou, Xiao, Wu, Min-Zhi, Jiang, Ting-Ting, Chen, Xiang-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594522/
https://www.ncbi.nlm.nih.gov/pubmed/34433795
http://dx.doi.org/10.1097/OLQ.0000000000001538
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author Zhou, Xiao
Wu, Min-Zhi
Jiang, Ting-Ting
Chen, Xiang-Sheng
author_facet Zhou, Xiao
Wu, Min-Zhi
Jiang, Ting-Ting
Chen, Xiang-Sheng
author_sort Zhou, Xiao
collection PubMed
description Rapid emergence of syphilis and oral sexual behaviors has focused attention on oral syphilis, and published reports of cases with oral syphilis have increased in the recent decades. We performed a systematic literature review by searching articles from PubMed, EMBSE, and Google Scholar, looking for case reports or series that would potentially have the clinical characteristics and outcomes for each individual case with oral syphilis. A total of 145 cases with the infection, from 95 studies, were identified to include in our review. Two main clinical phenotypes (ulcerative lesions and mucous patches) appeared to be of particular relevance to oral manifestations. A solitary ulcer was mostly manifested as the lesion of primary syphilis (91.7%) preferentially located on the upper lip, tongue, palate, and buccal mucosa. The most affected anatomical site in the patients with single location involved was the tongue (37.5%), followed by the lips (29.5%), palates (19.3%), and buccal mucosa (6.8%). It is concluded that oral syphilis has its predominant clinical phenotypes although it can manifest in diverse manners.
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spelling pubmed-85945222021-11-19 Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series Zhou, Xiao Wu, Min-Zhi Jiang, Ting-Ting Chen, Xiang-Sheng Sex Transm Dis Reviews Rapid emergence of syphilis and oral sexual behaviors has focused attention on oral syphilis, and published reports of cases with oral syphilis have increased in the recent decades. We performed a systematic literature review by searching articles from PubMed, EMBSE, and Google Scholar, looking for case reports or series that would potentially have the clinical characteristics and outcomes for each individual case with oral syphilis. A total of 145 cases with the infection, from 95 studies, were identified to include in our review. Two main clinical phenotypes (ulcerative lesions and mucous patches) appeared to be of particular relevance to oral manifestations. A solitary ulcer was mostly manifested as the lesion of primary syphilis (91.7%) preferentially located on the upper lip, tongue, palate, and buccal mucosa. The most affected anatomical site in the patients with single location involved was the tongue (37.5%), followed by the lips (29.5%), palates (19.3%), and buccal mucosa (6.8%). It is concluded that oral syphilis has its predominant clinical phenotypes although it can manifest in diverse manners. Lippincott Williams & Wilkins 2021-12 2021-08-25 /pmc/articles/PMC8594522/ /pubmed/34433795 http://dx.doi.org/10.1097/OLQ.0000000000001538 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Sexually Transmitted Diseases Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Reviews
Zhou, Xiao
Wu, Min-Zhi
Jiang, Ting-Ting
Chen, Xiang-Sheng
Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title_full Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title_fullStr Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title_full_unstemmed Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title_short Oral Manifestations of Early Syphilis in Adults: A Systematic Review of Case Reports and Series
title_sort oral manifestations of early syphilis in adults: a systematic review of case reports and series
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594522/
https://www.ncbi.nlm.nih.gov/pubmed/34433795
http://dx.doi.org/10.1097/OLQ.0000000000001538
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