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Seronegative Erosive Arthritis Following SARS-CoV-2 Infection
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affecting mostly the respiratory system, but several other organs and systems can be involved. Extrapulmonary manifestations and autoimmune phenomena following SARS-CoV-2 infection are f...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594638/ https://www.ncbi.nlm.nih.gov/pubmed/34786669 http://dx.doi.org/10.1007/s40744-021-00395-9 |
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author | Drosos, Alexandros A. Pelechas, Eleftherios Voulgari, Paraskevi V. |
author_facet | Drosos, Alexandros A. Pelechas, Eleftherios Voulgari, Paraskevi V. |
author_sort | Drosos, Alexandros A. |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affecting mostly the respiratory system, but several other organs and systems can be involved. Extrapulmonary manifestations and autoimmune phenomena following SARS-CoV-2 infection are frequent events occurring during the first 2 weeks or in later stages of the disease course. These can be expressed as an isolated discovery of autoantibodies, mostly antinuclear or antiphospholipid antibodies, through to full-blown autoimmune organ-specific and systemic diseases. Joint pain is a frequent complain in most patients, but to our knowledge, frank arthritis has not been reported so far. A 46-year-old woman developed symmetrical polyarthritis 2 months after SARS-CoV-2 infection. Laboratory tests showed high acute phase reactants, while the immunological profile was negative. Hand and wrists X-rays revealed soft tissue swelling as well as bone erosions at the ulnar base of the third and fourth metacarpophalangeal joint of the right hand and carpal bones. The patient responded well to small doses of prednisone and methotrexate and after 4 months she had a sustained clinical and laboratory improvement. This is the first report making an association between SARS-CoV-2 infection and erosive polyarthritis. Physicians dealing with patients infected from SARS-CoV-2 should be aware for the possible development of musculoskeletal disorders, among them symmetrical polyarthritis. Thus, a close follow-up and monitoring is mandatory. |
format | Online Article Text |
id | pubmed-8594638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-85946382021-11-16 Seronegative Erosive Arthritis Following SARS-CoV-2 Infection Drosos, Alexandros A. Pelechas, Eleftherios Voulgari, Paraskevi V. Rheumatol Ther Case Report Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affecting mostly the respiratory system, but several other organs and systems can be involved. Extrapulmonary manifestations and autoimmune phenomena following SARS-CoV-2 infection are frequent events occurring during the first 2 weeks or in later stages of the disease course. These can be expressed as an isolated discovery of autoantibodies, mostly antinuclear or antiphospholipid antibodies, through to full-blown autoimmune organ-specific and systemic diseases. Joint pain is a frequent complain in most patients, but to our knowledge, frank arthritis has not been reported so far. A 46-year-old woman developed symmetrical polyarthritis 2 months after SARS-CoV-2 infection. Laboratory tests showed high acute phase reactants, while the immunological profile was negative. Hand and wrists X-rays revealed soft tissue swelling as well as bone erosions at the ulnar base of the third and fourth metacarpophalangeal joint of the right hand and carpal bones. The patient responded well to small doses of prednisone and methotrexate and after 4 months she had a sustained clinical and laboratory improvement. This is the first report making an association between SARS-CoV-2 infection and erosive polyarthritis. Physicians dealing with patients infected from SARS-CoV-2 should be aware for the possible development of musculoskeletal disorders, among them symmetrical polyarthritis. Thus, a close follow-up and monitoring is mandatory. Springer Healthcare 2021-11-16 /pmc/articles/PMC8594638/ /pubmed/34786669 http://dx.doi.org/10.1007/s40744-021-00395-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Report Drosos, Alexandros A. Pelechas, Eleftherios Voulgari, Paraskevi V. Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title | Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title_full | Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title_fullStr | Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title_full_unstemmed | Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title_short | Seronegative Erosive Arthritis Following SARS-CoV-2 Infection |
title_sort | seronegative erosive arthritis following sars-cov-2 infection |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594638/ https://www.ncbi.nlm.nih.gov/pubmed/34786669 http://dx.doi.org/10.1007/s40744-021-00395-9 |
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