Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis

The rising field of RNA modifications is stimulating massive research nowadays. m(6)A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser...

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Detalles Bibliográficos
Autores principales: Lasman, Lior, Hanna, Jacob H, Novershtern, Noa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594681/
https://www.ncbi.nlm.nih.gov/pubmed/34968239
http://dx.doi.org/10.3390/epigenomes4010005
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author Lasman, Lior
Hanna, Jacob H
Novershtern, Noa
author_facet Lasman, Lior
Hanna, Jacob H
Novershtern, Noa
author_sort Lasman, Lior
collection PubMed
description The rising field of RNA modifications is stimulating massive research nowadays. m(6)A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m(6)A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m(6)A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes.
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spelling pubmed-85946812021-12-28 Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis Lasman, Lior Hanna, Jacob H Novershtern, Noa Epigenomes Review The rising field of RNA modifications is stimulating massive research nowadays. m(6)A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m(6)A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m(6)A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes. MDPI 2020-03-14 /pmc/articles/PMC8594681/ /pubmed/34968239 http://dx.doi.org/10.3390/epigenomes4010005 Text en © 2020 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Lasman, Lior
Hanna, Jacob H
Novershtern, Noa
Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_full Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_fullStr Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_full_unstemmed Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_short Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_sort role of m(6)a in embryonic stem cell differentiation and in gametogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594681/
https://www.ncbi.nlm.nih.gov/pubmed/34968239
http://dx.doi.org/10.3390/epigenomes4010005
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