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Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study
In this observational pilot study, we investigated the impact of Dolutegravir, Raltegravir, Elvitegravir (Integrase Strand Transfer Inhibitors, INSTIs), or boosted Darunavir (a Protease Inhibitor, PI) in combination with two nucleoside reverstranscriptase inhibitors (Emtricitabine/Tenofovir disoprox...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594820/ https://www.ncbi.nlm.nih.gov/pubmed/34784398 http://dx.doi.org/10.1371/journal.pone.0260007 |
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author | Jianu, Cristian Itu-Mureşan, Corina Drugan, Cristina Filipescu, Irina Topan, Adriana Violeta Jianu, Mihaela Elena Morar, Ioana Iulia Bolboacă, Sorana D. |
author_facet | Jianu, Cristian Itu-Mureşan, Corina Drugan, Cristina Filipescu, Irina Topan, Adriana Violeta Jianu, Mihaela Elena Morar, Ioana Iulia Bolboacă, Sorana D. |
author_sort | Jianu, Cristian |
collection | PubMed |
description | In this observational pilot study, we investigated the impact of Dolutegravir, Raltegravir, Elvitegravir (Integrase Strand Transfer Inhibitors, INSTIs), or boosted Darunavir (a Protease Inhibitor, PI) in combination with two nucleoside reverstranscriptase inhibitors (Emtricitabine/Tenofovir disoproxil or Lamivudine/Tenofovir disoproxil, NRTI) on four interleukins (IL-4, IL-10, IL-13, and IL-21) as immune activation markers in naïve HIV(Human Immunodeficiency Virus)-infected patients during the first six months of combined standard-of-care antiretroviral therapy (cART). Newly diagnosed with HIV-infected subjects and without any disease that could affect the immune activation markers were evaluated. The patients’ physicians recommended the cART as standard-of-care and the ILs were measured before cART and six months of cART. The levels of CD4(+) T-cells count and CD4(+)/CD8(+) ratio significantly increased at six months (P-value<0.02) regardless of the drugs, INSTIs or PI. However, a CD4(+)/CD8(+) >1 was observed in 25% of patients treated with Raltegravir and half of those treated with Dolutegravir. At six months of cART, viral load was detectable in only 6/31 individuals. IL-21 had an undetectable level in 30/31 patients after six months of cART. Our results suggest the potency in restoring immune markers in HIV-infected patients with all investigated drugs. Dolutegravir showed a tendency to statistically significant changes in IL-4 and IL-10. A clinical trial with random allocation of medication and an extensive follow-up is needed to replicate this research and validate the usefulness of evaluated ILs as markers of cART effectiveness. |
format | Online Article Text |
id | pubmed-8594820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85948202021-11-17 Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study Jianu, Cristian Itu-Mureşan, Corina Drugan, Cristina Filipescu, Irina Topan, Adriana Violeta Jianu, Mihaela Elena Morar, Ioana Iulia Bolboacă, Sorana D. PLoS One Research Article In this observational pilot study, we investigated the impact of Dolutegravir, Raltegravir, Elvitegravir (Integrase Strand Transfer Inhibitors, INSTIs), or boosted Darunavir (a Protease Inhibitor, PI) in combination with two nucleoside reverstranscriptase inhibitors (Emtricitabine/Tenofovir disoproxil or Lamivudine/Tenofovir disoproxil, NRTI) on four interleukins (IL-4, IL-10, IL-13, and IL-21) as immune activation markers in naïve HIV(Human Immunodeficiency Virus)-infected patients during the first six months of combined standard-of-care antiretroviral therapy (cART). Newly diagnosed with HIV-infected subjects and without any disease that could affect the immune activation markers were evaluated. The patients’ physicians recommended the cART as standard-of-care and the ILs were measured before cART and six months of cART. The levels of CD4(+) T-cells count and CD4(+)/CD8(+) ratio significantly increased at six months (P-value<0.02) regardless of the drugs, INSTIs or PI. However, a CD4(+)/CD8(+) >1 was observed in 25% of patients treated with Raltegravir and half of those treated with Dolutegravir. At six months of cART, viral load was detectable in only 6/31 individuals. IL-21 had an undetectable level in 30/31 patients after six months of cART. Our results suggest the potency in restoring immune markers in HIV-infected patients with all investigated drugs. Dolutegravir showed a tendency to statistically significant changes in IL-4 and IL-10. A clinical trial with random allocation of medication and an extensive follow-up is needed to replicate this research and validate the usefulness of evaluated ILs as markers of cART effectiveness. Public Library of Science 2021-11-16 /pmc/articles/PMC8594820/ /pubmed/34784398 http://dx.doi.org/10.1371/journal.pone.0260007 Text en © 2021 Jianu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jianu, Cristian Itu-Mureşan, Corina Drugan, Cristina Filipescu, Irina Topan, Adriana Violeta Jianu, Mihaela Elena Morar, Ioana Iulia Bolboacă, Sorana D. Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title | Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title_full | Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title_fullStr | Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title_full_unstemmed | Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title_short | Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study |
title_sort | evaluation of several serum interleukins as markers for treatment effectiveness in naïve hiv infected patients: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594820/ https://www.ncbi.nlm.nih.gov/pubmed/34784398 http://dx.doi.org/10.1371/journal.pone.0260007 |
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