Cargando…

A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), can play a significant role in reducing the pro-inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Benkun, Goodwin, Michael, Saleem, Danial, Jiang, Wei, Tang, Jianguo, Chu, Yiwei, Munford, Robert S, Lu, Mingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594946/ https://www.ncbi.nlm.nih.gov/pubmed/34783310 http://dx.doi.org/10.7554/eLife.70938

Ejemplares similares

A host lipase prevents lipopolysaccharide-induced foam cell formation
por: Feng, Jintao, et al.
Publicado: (2021)

Stimulus-dependent Deacylation of Bacterial Lipopolysaccharide by Dendritic Cells
por: Lu, Mingfang, et al.
Publicado: (2003)

LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma
por: Qian, Guojun, et al.
Publicado: (2018)

In vitro synthesis of phospholipids with yeast phospholipase B, a phospholipid deacylating enzyme
por: Watanabe, Yasuo, et al.
Publicado: (2018)

Neutral Lipid Metabolism Influences Phospholipid Synthesis and Deacylation in Saccharomyces cerevisiae
por: Mora, Gabriel, et al.
Publicado: (2012)

Cervus and cucumis peptides ameliorates bone erosion in experimental arthritis by inhibiting osteoclastogenesis
por: Lin, Ze-Min, et al.
Publicado: (2019)

Chlorogenic acid ameliorated allergic rhinitis-related symptoms in mice by regulating Th17 cells
por: Shi, Zhaohui, et al.
Publicado: (2020)

The recombinant anti-TNF-α fusion protein ameliorates rheumatoid arthritis by the protective role of autophagy
por: Chen, Xiaole, et al.
Publicado: (2020)

Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions
por: Boughter, Christopher T, et al.
Publicado: (2023)

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity
por: Mendoza, Juan L, et al.
Publicado: (2020)

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
por: Trivedi, Shubhanshi, et al.
Publicado: (2020)

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
por: Giraud-Gatineau, Alexandre, et al.
Publicado: (2020)

Insights into mechanisms of graft-versus-host disease through humanised mouse models
por: Elhage, Amal, et al.
Publicado: (2022)

A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants
por: Hulme, Katina D, et al.
Publicado: (2021)

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
por: Milne, Kathryn, et al.
Publicado: (2021)

Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection
por: Matty, Molly A, et al.
Publicado: (2019)

MicroRNAs of the miR-17~92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression
por: Zhang, Xiang, et al.
Publicado: (2020)

A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish
por: Rolig, Annah S, et al.
Publicado: (2018)

Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
por: Costa, Vivian Vasconcelos, et al.
Publicado: (2022)

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
por: Laval, Thomas, et al.
Publicado: (2021)

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
por: Tomasek, Kathrin, et al.
Publicado: (2022)

Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines
por: SoRelle, Elliott D, et al.
Publicado: (2021)

Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
por: Maximova, Olga A, et al.
Publicado: (2021)

Correction: Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines
por: SoRelle, Elliott D, et al.
Publicado: (2021)

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target
por: Neogi, Ujjwal, et al.
Publicado: (2022)

MicroRNA-140-5p ameliorates the high glucose-induced apoptosis and inflammation through suppressing TLR4/NF-κB signaling pathway in human renal tubular epithelial cells
por: Su, Jie, et al.
Publicado: (2020)

NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase
por: Wani, Khursheed A, et al.
Publicado: (2021)

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
por: Fielding, Ceri Alan, et al.
Publicado: (2022)

Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal inflammation and modulate the gut microbiota in mice
por: Wang, Xiaoya, et al.
Publicado: (2022)

MicroRNA-223 decreases cell proliferation, migration, invasion, and enhances cell apoptosis in childhood acute lymphoblastic leukemia via targeting Forkhead box O 1
por: Li, Chunyu, et al.
Publicado: (2020)

Label-free imaging of immune cell dynamics in the living retina using adaptive optics
por: Joseph, Aby, et al.
Publicado: (2020)

Reactive oxygen species oxidize STING and suppress interferon production
por: Tao, Lili, et al.
Publicado: (2020)

Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound
por: Tamrakar, Sonam, et al.
Publicado: (2023)

Notum deacylates octanoylated ghrelin
por: Zhao, Yuguang, et al.
Publicado: (2021)

Expression profiles of genes associated with inflammatory responses and oxidative stress in lung after heat stroke
por: Liu, Zhaoyu, et al.
Publicado: (2020)

Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality
por: Badawy, Mohamed A, et al.
Publicado: (2021)

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages
por: Li, Jie, et al.
Publicado: (2020)

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection
por: Garrett, Meghan E, et al.
Publicado: (2022)

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota
por: Kreuk, Lieselotte SM, et al.
Publicado: (2019)

ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation
por: Tian, Miaomiao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tanrsk0ek31t00e5q8ainefpaj