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Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the...

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Autores principales: Gong, Pian, Zhang, Wei, He, Yan, Wang, Jianfeng, Li, Song, Chen, Songyu, Ye, Qingsong, Li, Mingchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595011/
https://www.ncbi.nlm.nih.gov/pubmed/34795764
http://dx.doi.org/10.1155/2021/2602871
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author Gong, Pian
Zhang, Wei
He, Yan
Wang, Jianfeng
Li, Song
Chen, Songyu
Ye, Qingsong
Li, Mingchang
author_facet Gong, Pian
Zhang, Wei
He, Yan
Wang, Jianfeng
Li, Song
Chen, Songyu
Ye, Qingsong
Li, Mingchang
author_sort Gong, Pian
collection PubMed
description Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment.
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spelling pubmed-85950112021-11-17 Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke Gong, Pian Zhang, Wei He, Yan Wang, Jianfeng Li, Song Chen, Songyu Ye, Qingsong Li, Mingchang Stem Cells Int Review Article Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment. Hindawi 2021-11-09 /pmc/articles/PMC8595011/ /pubmed/34795764 http://dx.doi.org/10.1155/2021/2602871 Text en Copyright © 2021 Pian Gong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gong, Pian
Zhang, Wei
He, Yan
Wang, Jianfeng
Li, Song
Chen, Songyu
Ye, Qingsong
Li, Mingchang
Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_full Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_fullStr Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_full_unstemmed Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_short Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_sort classification and characteristics of mesenchymal stem cells and its potential therapeutic mechanisms and applications against ischemic stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595011/
https://www.ncbi.nlm.nih.gov/pubmed/34795764
http://dx.doi.org/10.1155/2021/2602871
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