Cargando…

Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-κB/BCL-2 Signaling Pathway In Vitro and In Vivo

Increasing evidence indicates that nuclear factor, erythroid 2-like 3 (Nrf3) is connected with tumorigenesis. However, the relationship between Nrf3 and tumor drug resistance remains elusive. In this study, we investigated the effect and mechanism of action by which Nrf3 regulated the sensitivity of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Bi-Qing, Chen, Wan-Meng, Zhao, Jia, Hou, Wei, Tang, Jian-Cai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595022/ https://www.ncbi.nlm.nih.gov/pubmed/34795760 http://dx.doi.org/10.1155/2021/9355555

Ejemplares similares

Nrf3 alleviates oxidative stress and promotes the survival of colon cancer cells by activating AKT/BCL-2 signal pathway
por: Cai, Bi-Qing, et al.
Publicado: (2023)

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation
por: Fu, Jinbo, et al.
Publicado: (2019)

Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κB/STAT3-regulated proteins
por: Yang, Yushan, et al.
Publicado: (2020)

Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
por: Liu, Kun, et al.
Publicado: (2019)

12-Epi-Napelline Inhibits Leukemia Cell Proliferation via the PI3K/AKT Signaling Pathway In Vitro and In Vivo
por: Han, Jia, et al.
Publicado: (2021)

Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study
por: Hu, Xiaofen, et al.
Publicado: (2021)

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds
por: Cykowiak, Marta, et al.
Publicado: (2021)

Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice
por: Meng, Qing-Tao, et al.
Publicado: (2017)

Carnosol inhibits osteoclastogenesis in vivo and in vitro by blocking the RANKL-induced NF-κB signaling pathway
por: Cai, Pan, et al.
Publicado: (2022)

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
por: Ge, Hui, et al.
Publicado: (2017)

miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells
por: Meng, Xiaomin, et al.
Publicado: (2018)

N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm
por: Hou, Jingjing, et al.
Publicado: (2017)

Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro
por: He, Dewei, et al.
Publicado: (2021)

lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer
por: Li, Peilong, et al.
Publicado: (2017)

Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB †
por: Buhrmann, Constanze, et al.
Publicado: (2020)

lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer
por: Li, Peilong, et al.
Publicado: (2020)

1-MNA Ameliorates High Fat Diet-Induced Heart Injury by Upregulating Nrf2 Expression and Inhibiting NF-κB in vivo and in vitro
por: Song, Ziguang, et al.
Publicado: (2021)

Therapeutic effects of moxibustion simultaneously targeting Nrf2 and NF-κB in diabetic peripheral neuropathy
por: Li, Jia, et al.
Publicado: (2019)

Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways
por: Xu, Chang, et al.
Publicado: (2022)

Halofuginone inhibits tumorigenic progression of 5-FU-resistant human colorectal cancer HCT-15/FU cells by targeting miR-132-3p in vitro
por: Wang, Chen, et al.
Publicado: (2020)

NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis
por: Yao, J, et al.
Publicado: (2014)

5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro
por: Almanzar, Vanessa M. Diaz, et al.
Publicado: (2023)

TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats
por: Bi, Qi-rui, et al.
Publicado: (2016)

Curcumin prevents muscle damage by regulating NF-κB and Nrf2 pathways and improves performance: an in vivo model
por: Sahin, Kazim, et al.
Publicado: (2016)

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
por: Gao, Wen, et al.
Publicado: (2022)

Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2
por: Xu, Bing, et al.
Publicado: (2017)

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
por: Cykowiak, Marta, et al.
Publicado: (2021)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
por: Jiang, Zengxin, et al.
Publicado: (2022)

Atypical IκB Bcl3 enhances the generation of the NF-κB p52 homodimer
por: Pan, Wenfei, et al.
Publicado: (2022)

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
por: Bellezza, Ilaria, et al.
Publicado: (2010)

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells
por: Lee, Da-Young, et al.
Publicado: (2020)

Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU
por: Sang, Jing, et al.
Publicado: (2020)

Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-κB signaling in an Nrf2-dependent manner
por: Huang, Xiao-Ting, et al.
Publicado: (2019)

Stevioside attenuates osteoarthritis via regulating Nrf2/HO-1/NF-κB pathway
por: Wu, Jia, et al.
Publicado: (2022)

Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT-8/5-Fu human colorectal cancer cell line
por: Zhang, Chao, et al.
Publicado: (2018)

Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition
por: Chen, Wan-Meng, et al.
Publicado: (2023)

A Compensatory Role of NF-κB to p53 in Response to 5-FU–Based Chemotherapy for Gastric Cancer Cell Lines
por: Endo, Fumitaka, et al.
Publicado: (2014)

Inhibiting the NF-κB pathway enhances the antitumor effect of cabazitaxel by downregulating Bcl-2 in pancreatic cancer
por: Li, Zequn, et al.
Publicado: (2020)

S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway
por: Yang, Guang, et al.
Publicado: (2020)

A Novel EphA2 Inhibitor Exerts Beneficial Effects in PI-IBS in Vivo and in Vitro Models via Nrf2 and NF-κB Signaling Pathways
por: Zeng, Li, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ral7gssja4nmtj569823q2fb64