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Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China

In August 2019, a suspected outbreak of canine distemper was observed in a masked palm civet farm that also received stray civets and rescued wild civets in Henan Province of China. A virulent canine distemper virus (CDV) strain, named HN19, from vaccinated masked palm civets was the etiologic agent...

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Autores principales: Shi, Ning, Zhang, Le, Yu, Xiuhua, Zhu, Xiangyu, Zhang, Shu, Zhang, Daining, Duan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595205/
https://www.ncbi.nlm.nih.gov/pubmed/34805333
http://dx.doi.org/10.3389/fvets.2021.728238
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author Shi, Ning
Zhang, Le
Yu, Xiuhua
Zhu, Xiangyu
Zhang, Shu
Zhang, Daining
Duan, Ming
author_facet Shi, Ning
Zhang, Le
Yu, Xiuhua
Zhu, Xiangyu
Zhang, Shu
Zhang, Daining
Duan, Ming
author_sort Shi, Ning
collection PubMed
description In August 2019, a suspected outbreak of canine distemper was observed in a masked palm civet farm that also received stray civets and rescued wild civets in Henan Province of China. A virulent canine distemper virus (CDV) strain, named HN19, from vaccinated masked palm civets was the etiologic agent identified in this outbreak using RT-PCR and sequencing of the complete genome. Serological analysis indicated a lower positive rate of CDV-neutralizing antibody in wild civets than in captive civets. Phylogenetic analysis of viral hemagglutinin (H) and the complete genome showed high identities with Rockborn-like strains at the nucleotide (98.7~99.72%) and the closest nucleotide similarity with a strain that killed lesser pandas in China in 1997, but low identities with America-1 strains (vaccine strains). Most importantly, one distinct amino acid exchange in the H protein at position 540 Asp → Gly (D540G), which confers CDV with an improved ability to adapt and utilize the human receptor, was observed in HN19. This study represents the first reported outbreak of a Rockborn-like CDV strain infection in masked palm civets in China. Based on this report, the existence of Rockborn-like strains in Chinese wild animals may not only cause immune failure in captive animals, but may also confer increased zoonotic potential.
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spelling pubmed-85952052021-11-18 Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China Shi, Ning Zhang, Le Yu, Xiuhua Zhu, Xiangyu Zhang, Shu Zhang, Daining Duan, Ming Front Vet Sci Veterinary Science In August 2019, a suspected outbreak of canine distemper was observed in a masked palm civet farm that also received stray civets and rescued wild civets in Henan Province of China. A virulent canine distemper virus (CDV) strain, named HN19, from vaccinated masked palm civets was the etiologic agent identified in this outbreak using RT-PCR and sequencing of the complete genome. Serological analysis indicated a lower positive rate of CDV-neutralizing antibody in wild civets than in captive civets. Phylogenetic analysis of viral hemagglutinin (H) and the complete genome showed high identities with Rockborn-like strains at the nucleotide (98.7~99.72%) and the closest nucleotide similarity with a strain that killed lesser pandas in China in 1997, but low identities with America-1 strains (vaccine strains). Most importantly, one distinct amino acid exchange in the H protein at position 540 Asp → Gly (D540G), which confers CDV with an improved ability to adapt and utilize the human receptor, was observed in HN19. This study represents the first reported outbreak of a Rockborn-like CDV strain infection in masked palm civets in China. Based on this report, the existence of Rockborn-like strains in Chinese wild animals may not only cause immune failure in captive animals, but may also confer increased zoonotic potential. Frontiers Media S.A. 2021-11-03 /pmc/articles/PMC8595205/ /pubmed/34805333 http://dx.doi.org/10.3389/fvets.2021.728238 Text en Copyright © 2021 Shi, Zhang, Yu, Zhu, Zhang, Zhang and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Shi, Ning
Zhang, Le
Yu, Xiuhua
Zhu, Xiangyu
Zhang, Shu
Zhang, Daining
Duan, Ming
Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title_full Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title_fullStr Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title_full_unstemmed Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title_short Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China
title_sort insight into an outbreak of canine distemper virus infection in masked palm civets in china
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595205/
https://www.ncbi.nlm.nih.gov/pubmed/34805333
http://dx.doi.org/10.3389/fvets.2021.728238
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