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A movable type bioelectronics printing technology for modular fabrication of biosensors

Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requirement o...

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Detalles Bibliográficos
Autores principales: Yang, Muqun, Liu, Mingyang, Cheng, Jing, Wang, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595314/
https://www.ncbi.nlm.nih.gov/pubmed/34785705
http://dx.doi.org/10.1038/s41598-021-01741-1
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author Yang, Muqun
Liu, Mingyang
Cheng, Jing
Wang, Han
author_facet Yang, Muqun
Liu, Mingyang
Cheng, Jing
Wang, Han
author_sort Yang, Muqun
collection PubMed
description Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requirement of cleanroom facility and limited fabrication materials, which significantly restrict the development and utilization of biosensors. Here, we propose a movable type bioelectronics printing method for the fabrication of biosensors by directly transferring bioelectronic materials onto various substrates using pre-fabricated molds. This simple, low-cost, yet robust method facilitates on-demand printing of master molds of partial or complete circuits on both rigid or flexible substrates. With this method, bioactive materials such as enzymes can be directly transferred onto substrates together with other electronic components, without complex modification after electrode fabrication using conventional methods. For demonstration, a dual-channel flexible electrochemical biosensor was fabricated by the movable type bioelectronics printing method for continuous monitoring of glucose and lactate. The movable type bioelectronics printing technology holds advantages of repeatability, flexibility and low cost for fabrication of biosensors on rigid and flexible substrates, as well as direct transfer printing of bioactive materials, which greatly promotes small-scale production of biosensors.
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spelling pubmed-85953142021-11-17 A movable type bioelectronics printing technology for modular fabrication of biosensors Yang, Muqun Liu, Mingyang Cheng, Jing Wang, Han Sci Rep Article Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requirement of cleanroom facility and limited fabrication materials, which significantly restrict the development and utilization of biosensors. Here, we propose a movable type bioelectronics printing method for the fabrication of biosensors by directly transferring bioelectronic materials onto various substrates using pre-fabricated molds. This simple, low-cost, yet robust method facilitates on-demand printing of master molds of partial or complete circuits on both rigid or flexible substrates. With this method, bioactive materials such as enzymes can be directly transferred onto substrates together with other electronic components, without complex modification after electrode fabrication using conventional methods. For demonstration, a dual-channel flexible electrochemical biosensor was fabricated by the movable type bioelectronics printing method for continuous monitoring of glucose and lactate. The movable type bioelectronics printing technology holds advantages of repeatability, flexibility and low cost for fabrication of biosensors on rigid and flexible substrates, as well as direct transfer printing of bioactive materials, which greatly promotes small-scale production of biosensors. Nature Publishing Group UK 2021-11-16 /pmc/articles/PMC8595314/ /pubmed/34785705 http://dx.doi.org/10.1038/s41598-021-01741-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Muqun
Liu, Mingyang
Cheng, Jing
Wang, Han
A movable type bioelectronics printing technology for modular fabrication of biosensors
title A movable type bioelectronics printing technology for modular fabrication of biosensors
title_full A movable type bioelectronics printing technology for modular fabrication of biosensors
title_fullStr A movable type bioelectronics printing technology for modular fabrication of biosensors
title_full_unstemmed A movable type bioelectronics printing technology for modular fabrication of biosensors
title_short A movable type bioelectronics printing technology for modular fabrication of biosensors
title_sort movable type bioelectronics printing technology for modular fabrication of biosensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595314/
https://www.ncbi.nlm.nih.gov/pubmed/34785705
http://dx.doi.org/10.1038/s41598-021-01741-1
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