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Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey

The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on gut microbiome in residents. Here we investigated the relatio...

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Autores principales: Du, Yong, Ding, Lu, Na, Li, Sun, Ting, Sun, Xian, Wang, Liqun, He, Shulan, Wang, Zhizhong, Lu, Zhenhui, Li, Feng, Guo, Xiaofei, Zhang, Yanhong, Tian, Jin, Wang, Bo, Zhai, Sifan, Yang, Chao, Liu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595329/
https://www.ncbi.nlm.nih.gov/pubmed/34804988
http://dx.doi.org/10.3389/fcimb.2021.707402
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author Du, Yong
Ding, Lu
Na, Li
Sun, Ting
Sun, Xian
Wang, Liqun
He, Shulan
Wang, Zhizhong
Lu, Zhenhui
Li, Feng
Guo, Xiaofei
Zhang, Yanhong
Tian, Jin
Wang, Bo
Zhai, Sifan
Yang, Chao
Liu, Xiao
author_facet Du, Yong
Ding, Lu
Na, Li
Sun, Ting
Sun, Xian
Wang, Liqun
He, Shulan
Wang, Zhizhong
Lu, Zhenhui
Li, Feng
Guo, Xiaofei
Zhang, Yanhong
Tian, Jin
Wang, Bo
Zhai, Sifan
Yang, Chao
Liu, Xiao
author_sort Du, Yong
collection PubMed
description The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on gut microbiome in residents. Here we investigated the relation between living environment and gut microbiota in a homogenous population along an urban-rural gradient in Ningxia China. According to the degree of urbanization, the population is divided into four groups: mountainous rural (MR) represents non-urbanized areas, mountainous urban (MU) and plain rural (PR) represent preliminary urbanization, and plain urban (PU) is a representative of complete urbanization. Studies have found that with the deepening of urbanization, the prevalence of chronic diseases, such as diabetes, dyslipidemia, fatty liver, gallstones, and renal cysts, have gradually increased. The intestinal richness and diversity of the microbial community were significantly reduced in the PR and the PU groups compared with the MR and the MU groups. Based on linear discriminant analysis selection, the significantly enriched genera Faecalibacterium, Prevotella, and Pseudobutyrivibrio in the MR group gradually decreased in the MU, the PR, and the PU groups. Effect size results revealed that both residence and diet had an effect on intestinal microbiota. Our results suggested that the disparate patterns of gut microbiota composition were revealed at different levels of urbanization, providing an opportunity to understand the pathogenesis of chronic diseases and the contribution of the “rural microbiome” in potential protection against the occurrence of chronic diseases.
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spelling pubmed-85953292021-11-18 Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey Du, Yong Ding, Lu Na, Li Sun, Ting Sun, Xian Wang, Liqun He, Shulan Wang, Zhizhong Lu, Zhenhui Li, Feng Guo, Xiaofei Zhang, Yanhong Tian, Jin Wang, Bo Zhai, Sifan Yang, Chao Liu, Xiao Front Cell Infect Microbiol Cellular and Infection Microbiology The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on gut microbiome in residents. Here we investigated the relation between living environment and gut microbiota in a homogenous population along an urban-rural gradient in Ningxia China. According to the degree of urbanization, the population is divided into four groups: mountainous rural (MR) represents non-urbanized areas, mountainous urban (MU) and plain rural (PR) represent preliminary urbanization, and plain urban (PU) is a representative of complete urbanization. Studies have found that with the deepening of urbanization, the prevalence of chronic diseases, such as diabetes, dyslipidemia, fatty liver, gallstones, and renal cysts, have gradually increased. The intestinal richness and diversity of the microbial community were significantly reduced in the PR and the PU groups compared with the MR and the MU groups. Based on linear discriminant analysis selection, the significantly enriched genera Faecalibacterium, Prevotella, and Pseudobutyrivibrio in the MR group gradually decreased in the MU, the PR, and the PU groups. Effect size results revealed that both residence and diet had an effect on intestinal microbiota. Our results suggested that the disparate patterns of gut microbiota composition were revealed at different levels of urbanization, providing an opportunity to understand the pathogenesis of chronic diseases and the contribution of the “rural microbiome” in potential protection against the occurrence of chronic diseases. Frontiers Media S.A. 2021-11-03 /pmc/articles/PMC8595329/ /pubmed/34804988 http://dx.doi.org/10.3389/fcimb.2021.707402 Text en Copyright © 2021 Du, Ding, Na, Sun, Sun, Wang, He, Wang, Lu, Li, Guo, Zhang, Tian, Wang, Zhai, Yang and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Du, Yong
Ding, Lu
Na, Li
Sun, Ting
Sun, Xian
Wang, Liqun
He, Shulan
Wang, Zhizhong
Lu, Zhenhui
Li, Feng
Guo, Xiaofei
Zhang, Yanhong
Tian, Jin
Wang, Bo
Zhai, Sifan
Yang, Chao
Liu, Xiao
Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title_full Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title_fullStr Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title_full_unstemmed Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title_short Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
title_sort prevalence of chronic diseases and alterations of gut microbiome in people of ningxia china during urbanization: an epidemiological survey
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595329/
https://www.ncbi.nlm.nih.gov/pubmed/34804988
http://dx.doi.org/10.3389/fcimb.2021.707402
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