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The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease

Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammator...

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Autores principales: Kono, Masamitsu, Nanushaj, Denisa, Sakatani, Hideki, Murakami, Daichi, Hijiya, Masayoshi, Kinoshita, Tetsuya, Shiga, Tatsuya, Kaneko, Fumie, Enomoto, Keisuke, Sugita, Gen, Miyajima, Masayasu, Okada, Yuka, Saika, Shizuya, Hotomi, Muneki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595402/
https://www.ncbi.nlm.nih.gov/pubmed/34804016
http://dx.doi.org/10.3389/fimmu.2021.732029
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author Kono, Masamitsu
Nanushaj, Denisa
Sakatani, Hideki
Murakami, Daichi
Hijiya, Masayoshi
Kinoshita, Tetsuya
Shiga, Tatsuya
Kaneko, Fumie
Enomoto, Keisuke
Sugita, Gen
Miyajima, Masayasu
Okada, Yuka
Saika, Shizuya
Hotomi, Muneki
author_facet Kono, Masamitsu
Nanushaj, Denisa
Sakatani, Hideki
Murakami, Daichi
Hijiya, Masayoshi
Kinoshita, Tetsuya
Shiga, Tatsuya
Kaneko, Fumie
Enomoto, Keisuke
Sugita, Gen
Miyajima, Masayasu
Okada, Yuka
Saika, Shizuya
Hotomi, Muneki
author_sort Kono, Masamitsu
collection PubMed
description Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections. Streptococcus pneumoniae can cause severe infections such as pneumonia, bacteremia, and meningitis, with systemic inflammatory responses. This study examines the role of TRP channels (TRPV1 and TRPV4) for pneumococcal nasal colonization and subsequent development of invasive pneumococcal disease in a mouse model. Both TRPV1 and TRPV4 channels were shown to be related to regulation of the development of pneumococcal diseases. In particular, the influx of neutrophils (polymorphonuclear cells) in the nasal cavity and the bactericidal activity were significantly suppressed among TRPV4 knockout mice. This may lead to severe pneumococcal pneumonia, resulting in dissemination of the bacteria to various organs and causing high mortality during influenza virus coinfection. Regulating host immune responses by TRP channels could be a novel strategy against pathogenic microorganisms causing strong local/systemic inflammation.
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spelling pubmed-85954022021-11-18 The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease Kono, Masamitsu Nanushaj, Denisa Sakatani, Hideki Murakami, Daichi Hijiya, Masayoshi Kinoshita, Tetsuya Shiga, Tatsuya Kaneko, Fumie Enomoto, Keisuke Sugita, Gen Miyajima, Masayasu Okada, Yuka Saika, Shizuya Hotomi, Muneki Front Immunol Immunology Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections. Streptococcus pneumoniae can cause severe infections such as pneumonia, bacteremia, and meningitis, with systemic inflammatory responses. This study examines the role of TRP channels (TRPV1 and TRPV4) for pneumococcal nasal colonization and subsequent development of invasive pneumococcal disease in a mouse model. Both TRPV1 and TRPV4 channels were shown to be related to regulation of the development of pneumococcal diseases. In particular, the influx of neutrophils (polymorphonuclear cells) in the nasal cavity and the bactericidal activity were significantly suppressed among TRPV4 knockout mice. This may lead to severe pneumococcal pneumonia, resulting in dissemination of the bacteria to various organs and causing high mortality during influenza virus coinfection. Regulating host immune responses by TRP channels could be a novel strategy against pathogenic microorganisms causing strong local/systemic inflammation. Frontiers Media S.A. 2021-11-03 /pmc/articles/PMC8595402/ /pubmed/34804016 http://dx.doi.org/10.3389/fimmu.2021.732029 Text en Copyright © 2021 Kono, Nanushaj, Sakatani, Murakami, Hijiya, Kinoshita, Shiga, Kaneko, Enomoto, Sugita, Miyajima, Okada, Saika and Hotomi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kono, Masamitsu
Nanushaj, Denisa
Sakatani, Hideki
Murakami, Daichi
Hijiya, Masayoshi
Kinoshita, Tetsuya
Shiga, Tatsuya
Kaneko, Fumie
Enomoto, Keisuke
Sugita, Gen
Miyajima, Masayasu
Okada, Yuka
Saika, Shizuya
Hotomi, Muneki
The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title_full The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title_fullStr The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title_full_unstemmed The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title_short The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
title_sort roles of transient receptor potential vanilloid 1 and 4 in pneumococcal nasal colonization and subsequent development of invasive disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595402/
https://www.ncbi.nlm.nih.gov/pubmed/34804016
http://dx.doi.org/10.3389/fimmu.2021.732029
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