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The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease
Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammator...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595402/ https://www.ncbi.nlm.nih.gov/pubmed/34804016 http://dx.doi.org/10.3389/fimmu.2021.732029 |
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author | Kono, Masamitsu Nanushaj, Denisa Sakatani, Hideki Murakami, Daichi Hijiya, Masayoshi Kinoshita, Tetsuya Shiga, Tatsuya Kaneko, Fumie Enomoto, Keisuke Sugita, Gen Miyajima, Masayasu Okada, Yuka Saika, Shizuya Hotomi, Muneki |
author_facet | Kono, Masamitsu Nanushaj, Denisa Sakatani, Hideki Murakami, Daichi Hijiya, Masayoshi Kinoshita, Tetsuya Shiga, Tatsuya Kaneko, Fumie Enomoto, Keisuke Sugita, Gen Miyajima, Masayasu Okada, Yuka Saika, Shizuya Hotomi, Muneki |
author_sort | Kono, Masamitsu |
collection | PubMed |
description | Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections. Streptococcus pneumoniae can cause severe infections such as pneumonia, bacteremia, and meningitis, with systemic inflammatory responses. This study examines the role of TRP channels (TRPV1 and TRPV4) for pneumococcal nasal colonization and subsequent development of invasive pneumococcal disease in a mouse model. Both TRPV1 and TRPV4 channels were shown to be related to regulation of the development of pneumococcal diseases. In particular, the influx of neutrophils (polymorphonuclear cells) in the nasal cavity and the bactericidal activity were significantly suppressed among TRPV4 knockout mice. This may lead to severe pneumococcal pneumonia, resulting in dissemination of the bacteria to various organs and causing high mortality during influenza virus coinfection. Regulating host immune responses by TRP channels could be a novel strategy against pathogenic microorganisms causing strong local/systemic inflammation. |
format | Online Article Text |
id | pubmed-8595402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85954022021-11-18 The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease Kono, Masamitsu Nanushaj, Denisa Sakatani, Hideki Murakami, Daichi Hijiya, Masayoshi Kinoshita, Tetsuya Shiga, Tatsuya Kaneko, Fumie Enomoto, Keisuke Sugita, Gen Miyajima, Masayasu Okada, Yuka Saika, Shizuya Hotomi, Muneki Front Immunol Immunology Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections. Streptococcus pneumoniae can cause severe infections such as pneumonia, bacteremia, and meningitis, with systemic inflammatory responses. This study examines the role of TRP channels (TRPV1 and TRPV4) for pneumococcal nasal colonization and subsequent development of invasive pneumococcal disease in a mouse model. Both TRPV1 and TRPV4 channels were shown to be related to regulation of the development of pneumococcal diseases. In particular, the influx of neutrophils (polymorphonuclear cells) in the nasal cavity and the bactericidal activity were significantly suppressed among TRPV4 knockout mice. This may lead to severe pneumococcal pneumonia, resulting in dissemination of the bacteria to various organs and causing high mortality during influenza virus coinfection. Regulating host immune responses by TRP channels could be a novel strategy against pathogenic microorganisms causing strong local/systemic inflammation. Frontiers Media S.A. 2021-11-03 /pmc/articles/PMC8595402/ /pubmed/34804016 http://dx.doi.org/10.3389/fimmu.2021.732029 Text en Copyright © 2021 Kono, Nanushaj, Sakatani, Murakami, Hijiya, Kinoshita, Shiga, Kaneko, Enomoto, Sugita, Miyajima, Okada, Saika and Hotomi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kono, Masamitsu Nanushaj, Denisa Sakatani, Hideki Murakami, Daichi Hijiya, Masayoshi Kinoshita, Tetsuya Shiga, Tatsuya Kaneko, Fumie Enomoto, Keisuke Sugita, Gen Miyajima, Masayasu Okada, Yuka Saika, Shizuya Hotomi, Muneki The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title | The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title_full | The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title_fullStr | The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title_full_unstemmed | The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title_short | The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease |
title_sort | roles of transient receptor potential vanilloid 1 and 4 in pneumococcal nasal colonization and subsequent development of invasive disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595402/ https://www.ncbi.nlm.nih.gov/pubmed/34804016 http://dx.doi.org/10.3389/fimmu.2021.732029 |
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