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Simultaneous functional MRI of two awake marmosets

Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using function...

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Autores principales: Gilbert, Kyle M., Cléry, Justine C., Gati, Joseph S., Hori, Yuki, Johnston, Kevin D., Mashkovtsev, Alexander, Selvanayagam, Janahan, Zeman, Peter, Menon, Ravi S., Schaeffer, David J., Everling, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595428/
https://www.ncbi.nlm.nih.gov/pubmed/34785685
http://dx.doi.org/10.1038/s41467-021-26976-4
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author Gilbert, Kyle M.
Cléry, Justine C.
Gati, Joseph S.
Hori, Yuki
Johnston, Kevin D.
Mashkovtsev, Alexander
Selvanayagam, Janahan
Zeman, Peter
Menon, Ravi S.
Schaeffer, David J.
Everling, Stefan
author_facet Gilbert, Kyle M.
Cléry, Justine C.
Gati, Joseph S.
Hori, Yuki
Johnston, Kevin D.
Mashkovtsev, Alexander
Selvanayagam, Janahan
Zeman, Peter
Menon, Ravi S.
Schaeffer, David J.
Everling, Stefan
author_sort Gilbert, Kyle M.
collection PubMed
description Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, the brain activation of a marmoset when viewing a second marmoset in-person versus when viewing a pre-recorded video of the same marmoset—i.e., when either capable or incapable of socially interacting with a visible conspecific—demonstrates increased activation in the face-patch network. This method enables a wide range of possibilities for potentially studying social function and dysfunction in a non-human primate model.
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spelling pubmed-85954282021-11-19 Simultaneous functional MRI of two awake marmosets Gilbert, Kyle M. Cléry, Justine C. Gati, Joseph S. Hori, Yuki Johnston, Kevin D. Mashkovtsev, Alexander Selvanayagam, Janahan Zeman, Peter Menon, Ravi S. Schaeffer, David J. Everling, Stefan Nat Commun Article Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, the brain activation of a marmoset when viewing a second marmoset in-person versus when viewing a pre-recorded video of the same marmoset—i.e., when either capable or incapable of socially interacting with a visible conspecific—demonstrates increased activation in the face-patch network. This method enables a wide range of possibilities for potentially studying social function and dysfunction in a non-human primate model. Nature Publishing Group UK 2021-11-16 /pmc/articles/PMC8595428/ /pubmed/34785685 http://dx.doi.org/10.1038/s41467-021-26976-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gilbert, Kyle M.
Cléry, Justine C.
Gati, Joseph S.
Hori, Yuki
Johnston, Kevin D.
Mashkovtsev, Alexander
Selvanayagam, Janahan
Zeman, Peter
Menon, Ravi S.
Schaeffer, David J.
Everling, Stefan
Simultaneous functional MRI of two awake marmosets
title Simultaneous functional MRI of two awake marmosets
title_full Simultaneous functional MRI of two awake marmosets
title_fullStr Simultaneous functional MRI of two awake marmosets
title_full_unstemmed Simultaneous functional MRI of two awake marmosets
title_short Simultaneous functional MRI of two awake marmosets
title_sort simultaneous functional mri of two awake marmosets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595428/
https://www.ncbi.nlm.nih.gov/pubmed/34785685
http://dx.doi.org/10.1038/s41467-021-26976-4
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