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Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) a...

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Autores principales: Fink, Thais T., Marques, Heloisa H.S., Gualano, Bruno, Lindoso, Livia, Bain, Vera, Astley, Camilla, Martins, Fernanda, Matheus, Denise, Matsuo, Olivia M., Suguita, Priscila, Trindade, Vitor, Paula, Camila S.Y., Farhat, Sylvia C.L., Palmeira, Patricia, Leal, Gabriela N., Suzuki, Lisa, Odone, Vicente, Carneiro-Sampaio, Magda, Duarte, Alberto José S., Antonangelo, Leila, Batisttella, Linamara R., Polanczyk, Guilherme V., Pereira, Rosa Maria R., Carvalho, Carlos Roberto R., Buchpiguel, Carlos A., Xavier, Ana Claudia L., Seelaender, Marilia, Silva, Clovis Artur, Pereira, Maria Fernanda B., Sallum, Adriana M. E., Brentani, Alexandra V. M., Neto, Álvaro José S., Ihara, Amanda, Santos, Andrea R., Canton, Ana Pinheiro M., Watanabe, Andreia, dos Santos, Angélica C., Pastorino, Antonio C., Franco, Bernadette D. G. M., Caruzo, Bruna, Ceneviva, Carina, Martins, Carolina C. M. F., Prado, Danilo, Abellan, Deipara M., Benatti, Fabiana B., Smaria, Fabiana, Gonçalves, Fernanda T., Penteado, Fernando D., de Castro, Gabriela S. F., Gonçalves, Guilherme S., Roschel, Hamilton, Disi, Ilana R., Marques, Isabela G., Castro, Inar A., Buscatti, Izabel M., Faiad, Jaline Z., Fiamoncini, Jarlei, Rodrigues, Joaquim C., Carneiro, Jorge D. A., Paz, Jose A., Ferreira, Juliana C., Ferreira, Juliana C. O., Silva, Katia R., Bastos, Karina L. M., Kozu, Katia, Cristofani, Lilian M., Souza, Lucas V. B., Campos, Lucia M. A., Silva, Luiz Vicente R. F., Sapienza, Marcelo T., Lima, Marcos S., Garanito, Marlene P., Santos, Márcia F. A., Dorna, Mayra B., Aikawa, Nadia E., Litvinov, Nadia, Sakita, Neusa K., Gaiolla, Paula V. V., Pasqualucci, Paula, Toma, Ricardo K., Correa-Silva, Simone, Sieczkowska, Sofia M., Imamura, Marta, Forsait, Silvana, Santos, Vera A., Zheng, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Medicina / USP 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595593/
https://www.ncbi.nlm.nih.gov/pubmed/34852145
http://dx.doi.org/10.6061/clinics/2021/e3511
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author Fink, Thais T.
Marques, Heloisa H.S.
Gualano, Bruno
Lindoso, Livia
Bain, Vera
Astley, Camilla
Martins, Fernanda
Matheus, Denise
Matsuo, Olivia M.
Suguita, Priscila
Trindade, Vitor
Paula, Camila S.Y.
Farhat, Sylvia C.L.
Palmeira, Patricia
Leal, Gabriela N.
Suzuki, Lisa
Odone, Vicente
Carneiro-Sampaio, Magda
Duarte, Alberto José S.
Antonangelo, Leila
Batisttella, Linamara R.
Polanczyk, Guilherme V.
Pereira, Rosa Maria R.
Carvalho, Carlos Roberto R.
Buchpiguel, Carlos A.
Xavier, Ana Claudia L.
Seelaender, Marilia
Silva, Clovis Artur
Pereira, Maria Fernanda B.
Sallum, Adriana M. E.
Brentani, Alexandra V. M.
Neto, Álvaro José S.
Ihara, Amanda
Santos, Andrea R.
Canton, Ana Pinheiro M.
Watanabe, Andreia
dos Santos, Angélica C.
Pastorino, Antonio C.
Franco, Bernadette D. G. M.
Caruzo, Bruna
Ceneviva, Carina
Martins, Carolina C. M. F.
Prado, Danilo
Abellan, Deipara M.
Benatti, Fabiana B.
Smaria, Fabiana
Gonçalves, Fernanda T.
Penteado, Fernando D.
de Castro, Gabriela S. F.
Gonçalves, Guilherme S.
Roschel, Hamilton
Disi, Ilana R.
Marques, Isabela G.
Castro, Inar A.
Buscatti, Izabel M.
Faiad, Jaline Z.
Fiamoncini, Jarlei
Rodrigues, Joaquim C.
Carneiro, Jorge D. A.
Paz, Jose A.
Ferreira, Juliana C.
Ferreira, Juliana C. O.
Silva, Katia R.
Bastos, Karina L. M.
Kozu, Katia
Cristofani, Lilian M.
Souza, Lucas V. B.
Campos, Lucia M. A.
Silva, Luiz Vicente R. F.
Sapienza, Marcelo T.
Lima, Marcos S.
Garanito, Marlene P.
Santos, Márcia F. A.
Dorna, Mayra B.
Aikawa, Nadia E.
Litvinov, Nadia
Sakita, Neusa K.
Gaiolla, Paula V. V.
Pasqualucci, Paula
Toma, Ricardo K.
Correa-Silva, Simone
Sieczkowska, Sofia M.
Imamura, Marta
Forsait, Silvana
Santos, Vera A.
Zheng, Yingying
author_facet Fink, Thais T.
Marques, Heloisa H.S.
Gualano, Bruno
Lindoso, Livia
Bain, Vera
Astley, Camilla
Martins, Fernanda
Matheus, Denise
Matsuo, Olivia M.
Suguita, Priscila
Trindade, Vitor
Paula, Camila S.Y.
Farhat, Sylvia C.L.
Palmeira, Patricia
Leal, Gabriela N.
Suzuki, Lisa
Odone, Vicente
Carneiro-Sampaio, Magda
Duarte, Alberto José S.
Antonangelo, Leila
Batisttella, Linamara R.
Polanczyk, Guilherme V.
Pereira, Rosa Maria R.
Carvalho, Carlos Roberto R.
Buchpiguel, Carlos A.
Xavier, Ana Claudia L.
Seelaender, Marilia
Silva, Clovis Artur
Pereira, Maria Fernanda B.
Sallum, Adriana M. E.
Brentani, Alexandra V. M.
Neto, Álvaro José S.
Ihara, Amanda
Santos, Andrea R.
Canton, Ana Pinheiro M.
Watanabe, Andreia
dos Santos, Angélica C.
Pastorino, Antonio C.
Franco, Bernadette D. G. M.
Caruzo, Bruna
Ceneviva, Carina
Martins, Carolina C. M. F.
Prado, Danilo
Abellan, Deipara M.
Benatti, Fabiana B.
Smaria, Fabiana
Gonçalves, Fernanda T.
Penteado, Fernando D.
de Castro, Gabriela S. F.
Gonçalves, Guilherme S.
Roschel, Hamilton
Disi, Ilana R.
Marques, Isabela G.
Castro, Inar A.
Buscatti, Izabel M.
Faiad, Jaline Z.
Fiamoncini, Jarlei
Rodrigues, Joaquim C.
Carneiro, Jorge D. A.
Paz, Jose A.
Ferreira, Juliana C.
Ferreira, Juliana C. O.
Silva, Katia R.
Bastos, Karina L. M.
Kozu, Katia
Cristofani, Lilian M.
Souza, Lucas V. B.
Campos, Lucia M. A.
Silva, Luiz Vicente R. F.
Sapienza, Marcelo T.
Lima, Marcos S.
Garanito, Marlene P.
Santos, Márcia F. A.
Dorna, Mayra B.
Aikawa, Nadia E.
Litvinov, Nadia
Sakita, Neusa K.
Gaiolla, Paula V. V.
Pasqualucci, Paula
Toma, Ricardo K.
Correa-Silva, Simone
Sieczkowska, Sofia M.
Imamura, Marta
Forsait, Silvana
Santos, Vera A.
Zheng, Yingying
author_sort Fink, Thais T.
collection PubMed
description OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
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spelling pubmed-85955932021-11-19 Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital Fink, Thais T. Marques, Heloisa H.S. Gualano, Bruno Lindoso, Livia Bain, Vera Astley, Camilla Martins, Fernanda Matheus, Denise Matsuo, Olivia M. Suguita, Priscila Trindade, Vitor Paula, Camila S.Y. Farhat, Sylvia C.L. Palmeira, Patricia Leal, Gabriela N. Suzuki, Lisa Odone, Vicente Carneiro-Sampaio, Magda Duarte, Alberto José S. Antonangelo, Leila Batisttella, Linamara R. Polanczyk, Guilherme V. Pereira, Rosa Maria R. Carvalho, Carlos Roberto R. Buchpiguel, Carlos A. Xavier, Ana Claudia L. Seelaender, Marilia Silva, Clovis Artur Pereira, Maria Fernanda B. Sallum, Adriana M. E. Brentani, Alexandra V. M. Neto, Álvaro José S. Ihara, Amanda Santos, Andrea R. Canton, Ana Pinheiro M. Watanabe, Andreia dos Santos, Angélica C. Pastorino, Antonio C. Franco, Bernadette D. G. M. Caruzo, Bruna Ceneviva, Carina Martins, Carolina C. M. F. Prado, Danilo Abellan, Deipara M. Benatti, Fabiana B. Smaria, Fabiana Gonçalves, Fernanda T. Penteado, Fernando D. de Castro, Gabriela S. F. Gonçalves, Guilherme S. Roschel, Hamilton Disi, Ilana R. Marques, Isabela G. Castro, Inar A. Buscatti, Izabel M. Faiad, Jaline Z. Fiamoncini, Jarlei Rodrigues, Joaquim C. Carneiro, Jorge D. A. Paz, Jose A. Ferreira, Juliana C. Ferreira, Juliana C. O. Silva, Katia R. Bastos, Karina L. M. Kozu, Katia Cristofani, Lilian M. Souza, Lucas V. B. Campos, Lucia M. A. Silva, Luiz Vicente R. F. Sapienza, Marcelo T. Lima, Marcos S. Garanito, Marlene P. Santos, Márcia F. A. Dorna, Mayra B. Aikawa, Nadia E. Litvinov, Nadia Sakita, Neusa K. Gaiolla, Paula V. V. Pasqualucci, Paula Toma, Ricardo K. Correa-Silva, Simone Sieczkowska, Sofia M. Imamura, Marta Forsait, Silvana Santos, Vera A. Zheng, Yingying Clinics (Sao Paulo) Original Article OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19. Faculdade de Medicina / USP 2021-11-17 2021 /pmc/articles/PMC8595593/ /pubmed/34852145 http://dx.doi.org/10.6061/clinics/2021/e3511 Text en Copyright © 2021 CLINICS https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Fink, Thais T.
Marques, Heloisa H.S.
Gualano, Bruno
Lindoso, Livia
Bain, Vera
Astley, Camilla
Martins, Fernanda
Matheus, Denise
Matsuo, Olivia M.
Suguita, Priscila
Trindade, Vitor
Paula, Camila S.Y.
Farhat, Sylvia C.L.
Palmeira, Patricia
Leal, Gabriela N.
Suzuki, Lisa
Odone, Vicente
Carneiro-Sampaio, Magda
Duarte, Alberto José S.
Antonangelo, Leila
Batisttella, Linamara R.
Polanczyk, Guilherme V.
Pereira, Rosa Maria R.
Carvalho, Carlos Roberto R.
Buchpiguel, Carlos A.
Xavier, Ana Claudia L.
Seelaender, Marilia
Silva, Clovis Artur
Pereira, Maria Fernanda B.
Sallum, Adriana M. E.
Brentani, Alexandra V. M.
Neto, Álvaro José S.
Ihara, Amanda
Santos, Andrea R.
Canton, Ana Pinheiro M.
Watanabe, Andreia
dos Santos, Angélica C.
Pastorino, Antonio C.
Franco, Bernadette D. G. M.
Caruzo, Bruna
Ceneviva, Carina
Martins, Carolina C. M. F.
Prado, Danilo
Abellan, Deipara M.
Benatti, Fabiana B.
Smaria, Fabiana
Gonçalves, Fernanda T.
Penteado, Fernando D.
de Castro, Gabriela S. F.
Gonçalves, Guilherme S.
Roschel, Hamilton
Disi, Ilana R.
Marques, Isabela G.
Castro, Inar A.
Buscatti, Izabel M.
Faiad, Jaline Z.
Fiamoncini, Jarlei
Rodrigues, Joaquim C.
Carneiro, Jorge D. A.
Paz, Jose A.
Ferreira, Juliana C.
Ferreira, Juliana C. O.
Silva, Katia R.
Bastos, Karina L. M.
Kozu, Katia
Cristofani, Lilian M.
Souza, Lucas V. B.
Campos, Lucia M. A.
Silva, Luiz Vicente R. F.
Sapienza, Marcelo T.
Lima, Marcos S.
Garanito, Marlene P.
Santos, Márcia F. A.
Dorna, Mayra B.
Aikawa, Nadia E.
Litvinov, Nadia
Sakita, Neusa K.
Gaiolla, Paula V. V.
Pasqualucci, Paula
Toma, Ricardo K.
Correa-Silva, Simone
Sieczkowska, Sofia M.
Imamura, Marta
Forsait, Silvana
Santos, Vera A.
Zheng, Yingying
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title_full Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title_fullStr Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title_full_unstemmed Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title_short Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
title_sort persistent symptoms and decreased health-related quality of life after symptomatic pediatric covid-19: a prospective study in a latin american tertiary hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595593/
https://www.ncbi.nlm.nih.gov/pubmed/34852145
http://dx.doi.org/10.6061/clinics/2021/e3511
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AT marquesisabelag persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT castroinara persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT buscattiizabelm persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT faiadjalinez persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT fiamoncinijarlei persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT rodriguesjoaquimc persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT carneirojorgeda persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT pazjosea persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT ferreirajulianac persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT ferreirajulianaco persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT silvakatiar persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT bastoskarinalm persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT kozukatia persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT cristofanililianm persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT souzalucasvb persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT camposluciama persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT silvaluizvicenterf persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT sapienzamarcelot persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT limamarcoss persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT garanitomarlenep persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT santosmarciafa persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT dornamayrab persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT aikawanadiae persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT litvinovnadia persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT sakitaneusak persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT gaiollapaulavv persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT pasqualuccipaula persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT tomaricardok persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT correasilvasimone persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT sieczkowskasofiam persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT imamuramarta persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT forsaitsilvana persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT santosveraa persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital
AT zhengyingying persistentsymptomsanddecreasedhealthrelatedqualityoflifeaftersymptomaticpediatriccovid19aprospectivestudyinalatinamericantertiaryhospital