Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPLs share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMRs), referred to as intracranial medulloepitheliomas. While Sonic hedgehog (SHH) and WN...

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Detalles Bibliográficos
Autores principales: Dottermusch, Matthias, Sumisławski, Piotr, Krevet, Julia, Middelkamp, Maximilian, Voß, Hannah, Siebels, Bente, Bartsch, Harald, Sotlar, Karl, Meyer, Peter, Frank, Stephan, Korshunov, Andrey, Glatzel, Markus, Schüller, Ulrich, Neumann, Julia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595639/
https://www.ncbi.nlm.nih.gov/pubmed/34785636
http://dx.doi.org/10.1038/s41389-021-00369-0

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