DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer

Triple-negative breast cancer (TNBC) is traditionally considered a glycolytic tumor with a poor prognosis while lacking targeted therapies. Here we show that high expression of dihydrolipoamide S-succinyltransferase (DLST), a tricarboxylic acid (TCA) cycle enzyme, predicts poor overall and recurrenc...

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Detalles Bibliográficos
Autores principales: Shen, Ning, Korm, Sovannarith, Karantanos, Theodoros, Li, Dun, Zhang, Xiaoyu, Ritou, Eleni, Xu, Hanfei, Lam, Andrew, English, Justin, Zong, Wei-Xing, Liu, Ching-Ti, Shirihai, Orian, Feng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595664/
https://www.ncbi.nlm.nih.gov/pubmed/34785772
http://dx.doi.org/10.1038/s42003-021-02805-8

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