Defective chromatin architectures in embryonic stem cells derived from somatic cell nuclear transfer impair their differentiation potentials

Nuclear transfer embryonic stem cells (ntESCs) hold enormous promise for individual-specific regenerative medicine. However, the chromatin states of ntESCs remain poorly characterized. In this study, we employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and three-dimensiona...

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Detalles Bibliográficos
Autores principales: Wu, Dan-Ya, Li, Xinxin, Sun, Qiao-Ran, Dou, Cheng-Li, Xu, Tian, He, Hainan, Luo, Han, Fu, Haitao, Bu, Guo-Wei, Luo, Bingbing, Zhang, Xia, Ma, Bin-Guang, Peng, Cheng, Miao, Yi-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595669/
https://www.ncbi.nlm.nih.gov/pubmed/34785659
http://dx.doi.org/10.1038/s41419-021-04384-2

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