Cargando…

Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis

Aberrant activation of the TGF-β/SMAD signaling pathway is often observed in hepatocellular carcinoma (HCC). Whether lncRNA regulates the TGF-β/SMAD signaling remains largely unknown. Here, we identified an oncogenic lncRNA that was upregulated in HCC and was transcriptionally induced by TGF-β (name...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Meng-Zhi, Yuan, Yi-chuan, Huang, Bi-Yu, Chen, Jin-Xi, Li, Bin-Kui, Fang, Jian-Hong, Zhuang, Shi-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595887/ https://www.ncbi.nlm.nih.gov/pubmed/34785655 http://dx.doi.org/10.1038/s41392-021-00781-3

Ejemplares similares

Correction: Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis
por: Wu, Meng-Zhi, et al.
Publicado: (2021)

Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa
por: Ekrikpo, Udeme E., et al.
Publicado: (2019)

miR-1269 Promotes Metastasis and Forms a Positive Feedback Loop with TGF-β
por: Bu, Pengcheng, et al.
Publicado: (2015)

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback
por: Gu, Wenchao, et al.
Publicado: (2015)

Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer
por: Lian, Jiayan, et al.
Publicado: (2015)

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop
por: Zhang, Y, et al.
Publicado: (2015)

SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
por: Tan, Kezhe, et al.
Publicado: (2022)

Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer
por: Shin, Sol-Bi, et al.
Publicado: (2019)

LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer
por: Lin, Hui, et al.
Publicado: (2022)

A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells
por: Liu, Jing-Jing, et al.
Publicado: (2014)

Correction: Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer
por: Shin, Sol-Bi, et al.
Publicado: (2019)

Solanine Inhibits Immune Escape Mediated by Hepatoma Treg Cells via the TGFβ/Smad Signaling Pathway
por: Gao, Juwei, et al.
Publicado: (2020)

Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis
por: Li, Hai-Yan, et al.
Publicado: (2015)

SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis
por: Lang, Chuandong, et al.
Publicado: (2020)

SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways
por: Liu, Lu, et al.
Publicado: (2021)

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
por: Xu, Yetao, et al.
Publicado: (2020)

Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells
por: Cao, Meng-Ting, et al.
Publicado: (2017)

A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance
por: Zhang, Li‐Zhen, et al.
Publicado: (2020)

Positive Feedback Promotes Oscillations in Negative Feedback Loops
por: Ananthasubramaniam, Bharath, et al.
Publicado: (2014)

KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma
por: Shen, Mao, et al.
Publicado: (2023)

Positive Feedback Loops in Alzheimer’s Disease: The Alzheimer’s Feedback Hypothesis
por: Doig, Andrew J.
Publicado: (2018)

Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling
por: Wang, Wenjuan, et al.
Publicado: (2021)

Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop
por: Zhou, Chong, et al.
Publicado: (2022)

A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer()()
por: Rojas, Andres, et al.
Publicado: (2016)

SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis
por: Du, Xing, et al.
Publicado: (2018)

miR-1306 Mediates the Feedback Regulation of the TGF-β/SMAD Signaling Pathway in Granulosa Cells
por: Yang, Liu, et al.
Publicado: (2019)

LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling
por: Zhang, Yiming, et al.
Publicado: (2023)

TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
por: Yu, Jia-Ray, et al.
Publicado: (2015)

LncRNA LINC00520 aggravates cell proliferation and migration in lung adenocarcinoma via a positive feedback loop
por: Huang, Wen, et al.
Publicado: (2021)

A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer
por: Zhu, Yiping, et al.
Publicado: (2021)

STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway
por: Wang, Yongxia, et al.
Publicado: (2018)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

Bleomycin (BLM) Induces Epithelial-to-Mesenchymal Transition in Cultured A549 Cells via the TGF-β/Smad Signaling Pathway
por: Chen, Kui-Jun, et al.
Publicado: (2016)

Negative feedback loop between ZBTB7A and TGF-β in breast cancer
por: Shen, Yingying, et al.
Publicado: (2017)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop
por: Gu, Junjie, et al.
Publicado: (2022)

Finding the positive feedback loops underlying multi-stationarity
por: Feliu, Elisenda, et al.
Publicado: (2015)

The positive feedback loop between ILF3 and lncRNA ILF3-AS1 promotes melanoma proliferation, migration, and invasion
por: Gao, Guozhen, et al.
Publicado: (2018)

HMMR promotes prostate cancer proliferation and metastasis via AURKA/mTORC2/E2F1 positive feedback loop
por: Guo, Kaixuan, et al.
Publicado: (2023)

TBL1X and Flot2 form a positive feedback loop to promote metastasis in nasopharyngeal carcinoma
por: Xu, Hongjuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_655sbhqooosfpfts6956js85be