Cargando…

A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies

WT2725 is a Wilms’ tumor gene 1 (WT1)-derived-oligopeptide vaccine designed to induce WT1-specific cytotoxic T-lymphocytes against WT1(+) tumors in human leukocyte antigen (HLA)-A*0201(+) and/or HLA-A*0206(+) patients. Here, we report the results of a phase I study of WT2725. In this phase I, open-l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Siqing, Piccioni, David E., Liu, Hongtao, Lukas, Rimas V., Kesari, Santosh, Aregawi, Dawit, Hong, David S., Yamaguchi, Kenichiro, Whicher, Kate, Zhang, Yi, Chen, Yu-Luan, Poola, Nagaraju, Eddy, John, Blum, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595891/ https://www.ncbi.nlm.nih.gov/pubmed/34785698 http://dx.doi.org/10.1038/s41598-021-01707-3

Ejemplares similares

MD2725: 16L2 aperture measurement
por: Mirarchi, Daniele, et al.
Publicado: (2018)

2725. Immunogenicity and Safety of a Booster Dose of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Adolescents and Adults
por: Hedrick, James, et al.
Publicado: (2019)

2725. Bacterial blood stream infections in Pediatric Liver Transplant Patients: Prevalence, Organisms and Risk factors. A Systematic review
por: Shieb, Mohamad, et al.
Publicado: (2023)

Lower mortality in distal femoral fractures in the presence of a knee arthroplasty: an observational study on 2,725 fractures from the Swedish Fracture Register
por: HERNEFALK, Björn, et al.
Publicado: (2022)

Phase I dose-escalation, safety, and CNS pharmacokinetic study of dexanabinol in patients with brain cancer
por: Juarez, Tiffany M, et al.
Publicado: (2021)

High-Thermal-Conductivity and High-Fluidity Heat Transfer Emulsion with 89 wt % Suspended Liquid Metal Microdroplets
por: Kim, Suyeon, et al.
Publicado: (2023)

Glucose-corrected standardized uptake value in the differentiation of high-grade glioma versus post-treatment changes
por: Nozawa, Asae, et al.
Publicado: (2015)

Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events
por: Wang, Xiaofeng, et al.
Publicado: (2021)

Comparison of Steroidogenic Exposure Following the Administration of Repository Corticotropin Injection With a Synthetic ACTH(1‐24) Depot and Methylprednisolone in Healthy Subjects
por: Wang, Xiaofeng, et al.
Publicado: (2020)

Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH(1‐24) Depot and Methylprednisolone in Healthy Subjects
por: Poola, Nagaraju, et al.
Publicado: (2021)

Phase Stability of Dross Particles in Hot-Dip Zn-55wt%Al-1.6wt%Si Galvanizing Bath
por: Qu, Dongdong, et al.
Publicado: (2023)

WT1 regulates angiogenesis in Ewing Sarcoma
por: Katuri, Varalakshmi, et al.
Publicado: (2014)

Scale-up of Emulsion Polymerisation up to 100 L and with a Polymer Content of up to 67 wt%, Monitored by Photon Density Wave Spectroscopy
por: Jacob, Laurence Isabelle, et al.
Publicado: (2022)

Tumor suppressor function of WT1 in acute promyelocytic leukemia
por: Christopher, Matthew J., et al.
Publicado: (2021)

WT1 peptide analogue WT1-126Y enhances leukemia lysis
por: Alqudaihi, Ghofran, et al.
Publicado: (2014)

Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics
por: Kato, Shumei, et al.
Publicado: (2015)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
por: Oji, Yusuke, et al.
Publicado: (2016)

WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia
por: Liu, Hongtao, et al.
Publicado: (2018)

Morphology and constitution of the compound layer formed on nitrided Fe–4wt.%V alloy
por: Hosmani, Santosh S., et al.
Publicado: (2009)

Food emulsions : principles, practice, and techniques /
por: McClements, David Julian
Publicado: (1999)

Isolating $Wt$ production at the LHC
por: White, Chris D., et al.
Publicado: (2009)

Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer
por: Schwaederle, Maria, et al.
Publicado: (2015)

WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1
por: Lv, Long, et al.
Publicado: (2015)

Fabrication and wear behaviour of Mg-3wt.%Al-x wt. % SiC composites
por: Jayasathyakawin, S., et al.
Publicado: (2023)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
por: Alzaaqi, Shouq, et al.
Publicado: (2022)

Wilms’ Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses
por: Uttenthal, Benjamin, et al.
Publicado: (2014)

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases
por: Nomura, Natsuko, et al.
Publicado: (2014)

Microstructure and Hot Deformation Behavior of the Mg–8 wt.% Sn–1.5 wt.% Al Alloy
por: Sun, Zhaoqian, et al.
Publicado: (2021)

Emulsions and emulsion technology.
por: Lissant, Kenneth J.
Publicado: (1974)

Mixing Time, Inversion and Multiple Emulsion Formation in a Limonene and Water Pickering Emulsion
por: Sawiak, Laura, et al.
Publicado: (2018)

Telomerase Reverse Transcriptase Promoter Alterations Across Cancer Types as Detected by Next-Generation Sequencing: A Clinical and Molecular Analysis of 423 Patients
por: Schwaederle, Maria, et al.
Publicado: (2017)

Editorial: WT1 in Development and Disease
por: Chau, You-Ying, et al.
Publicado: (2022)

Long term efficacy of WT1 peptide vaccine in patients with WT1 overexpressing hematopoeitic and solid malignancies
por: Letsch, Anne, et al.
Publicado: (2013)

Phase 1/2 study of the WT1 peptide cancer vaccine WT4869 in patients with myelodysplastic syndrome
por: Ueda, Yasunori, et al.
Publicado: (2017)

Co-Precipitation, Strength and Electrical Resistivity of Cu–26 wt % Ag–0.1 wt % Fe Alloy
por: Li, Rui, et al.
Publicado: (2017)

WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1
por: Oji, Yusuke, et al.
Publicado: (2023)

X-inactivation analysis of embryonic lethality in Ocrl(wt/−);Inpp5b(−/−) mice
por: Bernard, David J., et al.
Publicado: (2010)

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction
por: Fogal, Valentina, et al.
Publicado: (2014)

CXCR3 Signaling in BRAF(WT) Melanoma Increases IL-8 Expression and Tumorigenicity
por: Jenkins, Molly H., et al.
Publicado: (2015)

The effect of cyclic martensitic transformations on diffusion of cobalt atoms in Fe-18wt.%Mn-2wt.%Si alloy
por: Danilchenko, Vitaliy E, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9om7jdjtoagpktgb8ib8j26cb9