Cargando…

Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques

The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodriguez, Thalia, Dobrovolny, Hana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595996/
https://www.ncbi.nlm.nih.gov/pubmed/34804559
http://dx.doi.org/10.1098/rsos.202345
_version_ 1784600267195416576
author Rodriguez, Thalia
Dobrovolny, Hana M.
author_facet Rodriguez, Thalia
Dobrovolny, Hana M.
author_sort Rodriguez, Thalia
collection PubMed
description The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences in viral dynamics between SARS-CoV-2 infection in younger and older adults. In this study, we use previously published averaged viral titre measurements from the nose and throat of SARS-CoV-2 infection in young and aged cynomolgus macaques to parametrize a viral kinetics model. We find that all viral kinetics parameters differ between young and aged macaques in the nasal passages, but that there are fewer differences in parameter estimates from the throat. We further use our parametrized model to study the antiviral treatment of young and aged animals, finding that early antiviral treatment is more likely to lead to a lengthening of the infection in aged animals, but not in young animals.
format Online
Article
Text
id pubmed-8595996
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-85959962021-11-19 Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques Rodriguez, Thalia Dobrovolny, Hana M. R Soc Open Sci Mathematics The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences in viral dynamics between SARS-CoV-2 infection in younger and older adults. In this study, we use previously published averaged viral titre measurements from the nose and throat of SARS-CoV-2 infection in young and aged cynomolgus macaques to parametrize a viral kinetics model. We find that all viral kinetics parameters differ between young and aged macaques in the nasal passages, but that there are fewer differences in parameter estimates from the throat. We further use our parametrized model to study the antiviral treatment of young and aged animals, finding that early antiviral treatment is more likely to lead to a lengthening of the infection in aged animals, but not in young animals. The Royal Society 2021-11-17 /pmc/articles/PMC8595996/ /pubmed/34804559 http://dx.doi.org/10.1098/rsos.202345 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Mathematics
Rodriguez, Thalia
Dobrovolny, Hana M.
Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_full Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_fullStr Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_full_unstemmed Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_short Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_sort estimation of viral kinetics model parameters in young and aged sars-cov-2 infected macaques
topic Mathematics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595996/
https://www.ncbi.nlm.nih.gov/pubmed/34804559
http://dx.doi.org/10.1098/rsos.202345
work_keys_str_mv AT rodriguezthalia estimationofviralkineticsmodelparametersinyoungandagedsarscov2infectedmacaques
AT dobrovolnyhanam estimationofviralkineticsmodelparametersinyoungandagedsarscov2infectedmacaques