Cargando…

Early intervention is the key to success in COVID-19 control

New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level (AL) system that included strict stay-at-home orders. These interventions were successful in containing an outbreak and ultimately eliminating community transmission of COVID-19 in June 2020....

Descripción completa

Detalles Bibliográficos
Autores principales: Binny, Rachelle N., Baker, Michael G., Hendy, Shaun C., James, Alex, Lustig, Audrey, Plank, Michael J., Ridings, Kannan M., Steyn, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596003/
https://www.ncbi.nlm.nih.gov/pubmed/34804563
http://dx.doi.org/10.1098/rsos.210488
_version_ 1784600268717948928
author Binny, Rachelle N.
Baker, Michael G.
Hendy, Shaun C.
James, Alex
Lustig, Audrey
Plank, Michael J.
Ridings, Kannan M.
Steyn, Nicholas
author_facet Binny, Rachelle N.
Baker, Michael G.
Hendy, Shaun C.
James, Alex
Lustig, Audrey
Plank, Michael J.
Ridings, Kannan M.
Steyn, Nicholas
author_sort Binny, Rachelle N.
collection PubMed
description New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level (AL) system that included strict stay-at-home orders. These interventions were successful in containing an outbreak and ultimately eliminating community transmission of COVID-19 in June 2020. The timing of interventions is crucial to their success. Delaying interventions may reduce their effectiveness and mean that they need to be maintained for a longer period. We use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory in New Zealand's March–April 2020 outbreak and the effect of its interventions. We calculate key measures, including the number of reported cases and deaths, and the probability of elimination within a specified time frame. By comparing these measures under alternative timings of interventions, we show that changing the timing of AL4 (the strictest level of restrictions) has a far greater impact than the timing of border measures. Delaying AL4 restrictions results in considerably worse outcomes. Implementing border measures alone, without AL4 restrictions, is insufficient to control the outbreak. We conclude that the early introduction of stay-at-home orders was crucial in reducing the number of cases and deaths, enabling elimination.
format Online
Article
Text
id pubmed-8596003
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-85960032021-11-19 Early intervention is the key to success in COVID-19 control Binny, Rachelle N. Baker, Michael G. Hendy, Shaun C. James, Alex Lustig, Audrey Plank, Michael J. Ridings, Kannan M. Steyn, Nicholas R Soc Open Sci Mathematics New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level (AL) system that included strict stay-at-home orders. These interventions were successful in containing an outbreak and ultimately eliminating community transmission of COVID-19 in June 2020. The timing of interventions is crucial to their success. Delaying interventions may reduce their effectiveness and mean that they need to be maintained for a longer period. We use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory in New Zealand's March–April 2020 outbreak and the effect of its interventions. We calculate key measures, including the number of reported cases and deaths, and the probability of elimination within a specified time frame. By comparing these measures under alternative timings of interventions, we show that changing the timing of AL4 (the strictest level of restrictions) has a far greater impact than the timing of border measures. Delaying AL4 restrictions results in considerably worse outcomes. Implementing border measures alone, without AL4 restrictions, is insufficient to control the outbreak. We conclude that the early introduction of stay-at-home orders was crucial in reducing the number of cases and deaths, enabling elimination. The Royal Society 2021-11-17 /pmc/articles/PMC8596003/ /pubmed/34804563 http://dx.doi.org/10.1098/rsos.210488 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Mathematics
Binny, Rachelle N.
Baker, Michael G.
Hendy, Shaun C.
James, Alex
Lustig, Audrey
Plank, Michael J.
Ridings, Kannan M.
Steyn, Nicholas
Early intervention is the key to success in COVID-19 control
title Early intervention is the key to success in COVID-19 control
title_full Early intervention is the key to success in COVID-19 control
title_fullStr Early intervention is the key to success in COVID-19 control
title_full_unstemmed Early intervention is the key to success in COVID-19 control
title_short Early intervention is the key to success in COVID-19 control
title_sort early intervention is the key to success in covid-19 control
topic Mathematics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596003/
https://www.ncbi.nlm.nih.gov/pubmed/34804563
http://dx.doi.org/10.1098/rsos.210488
work_keys_str_mv AT binnyrachellen earlyinterventionisthekeytosuccessincovid19control
AT bakermichaelg earlyinterventionisthekeytosuccessincovid19control
AT hendyshaunc earlyinterventionisthekeytosuccessincovid19control
AT jamesalex earlyinterventionisthekeytosuccessincovid19control
AT lustigaudrey earlyinterventionisthekeytosuccessincovid19control
AT plankmichaelj earlyinterventionisthekeytosuccessincovid19control
AT ridingskannanm earlyinterventionisthekeytosuccessincovid19control
AT steynnicholas earlyinterventionisthekeytosuccessincovid19control