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A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment
INTRODUCTION: White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose‐specific energy deficit and improves cognitive outcomes in mild cognitive impairment (M...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596139/ https://www.ncbi.nlm.nih.gov/pubmed/34869825 http://dx.doi.org/10.1002/trc2.12217 |
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author | Roy, Maggie Fortier, Mélanie Rheault, François Edde, Manon Croteau, Etienne Castellano, Christian‐Alexandre Langlois, Francis St‐Pierre, Valérie Cuenoud, Bernard Bocti, Christian Fulop, Tamas Descoteaux, Maxime Cunnane, Stephen C. |
author_facet | Roy, Maggie Fortier, Mélanie Rheault, François Edde, Manon Croteau, Etienne Castellano, Christian‐Alexandre Langlois, Francis St‐Pierre, Valérie Cuenoud, Bernard Bocti, Christian Fulop, Tamas Descoteaux, Maxime Cunnane, Stephen C. |
author_sort | Roy, Maggie |
collection | PubMed |
description | INTRODUCTION: White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose‐specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or ketone uptake in specific WM fascicles in MCI has not previously been reported. METHODS: This 6‐month interventional study included MCI participants randomized to a placebo (n = 16) or ketogenic medium chain triglyceride (kMCT; n = 17) drink. A neurocognitive battery and brain imaging were performed pre‐ and post‐intervention. WM fascicle uptake of ketone and glucose and structural properties were assessed using positron emission tomography and diffusion imaging, respectively. RESULTS: Ketone uptake was increased in the kMCT group by 2.5‐ to 3.2‐fold in all nine WM fascicles of interest (P < .001), an effect seen both in deep WM and in fascicle cortical endpoints. Improvement in processing speed was positively associated with WM ketone uptake globally and in individual fascicles, most importantly the fornix (r = +0.61; P = .014). DISCUSSION: A 6‐month kMCT supplement improved WM energy supply in MCI by increasing ketone uptake in WM fascicles. The significant positive association with processing speed suggests that ketones may have a role in myelin integrity in MCI. |
format | Online Article Text |
id | pubmed-8596139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85961392021-12-02 A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment Roy, Maggie Fortier, Mélanie Rheault, François Edde, Manon Croteau, Etienne Castellano, Christian‐Alexandre Langlois, Francis St‐Pierre, Valérie Cuenoud, Bernard Bocti, Christian Fulop, Tamas Descoteaux, Maxime Cunnane, Stephen C. Alzheimers Dement (N Y) Research Articles INTRODUCTION: White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose‐specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or ketone uptake in specific WM fascicles in MCI has not previously been reported. METHODS: This 6‐month interventional study included MCI participants randomized to a placebo (n = 16) or ketogenic medium chain triglyceride (kMCT; n = 17) drink. A neurocognitive battery and brain imaging were performed pre‐ and post‐intervention. WM fascicle uptake of ketone and glucose and structural properties were assessed using positron emission tomography and diffusion imaging, respectively. RESULTS: Ketone uptake was increased in the kMCT group by 2.5‐ to 3.2‐fold in all nine WM fascicles of interest (P < .001), an effect seen both in deep WM and in fascicle cortical endpoints. Improvement in processing speed was positively associated with WM ketone uptake globally and in individual fascicles, most importantly the fornix (r = +0.61; P = .014). DISCUSSION: A 6‐month kMCT supplement improved WM energy supply in MCI by increasing ketone uptake in WM fascicles. The significant positive association with processing speed suggests that ketones may have a role in myelin integrity in MCI. John Wiley and Sons Inc. 2021-11-17 /pmc/articles/PMC8596139/ /pubmed/34869825 http://dx.doi.org/10.1002/trc2.12217 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Roy, Maggie Fortier, Mélanie Rheault, François Edde, Manon Croteau, Etienne Castellano, Christian‐Alexandre Langlois, Francis St‐Pierre, Valérie Cuenoud, Bernard Bocti, Christian Fulop, Tamas Descoteaux, Maxime Cunnane, Stephen C. A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title | A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title_full | A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title_fullStr | A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title_full_unstemmed | A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title_short | A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
title_sort | ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596139/ https://www.ncbi.nlm.nih.gov/pubmed/34869825 http://dx.doi.org/10.1002/trc2.12217 |
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