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Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased u...

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Detalles Bibliográficos
Autores principales: Xie, Yifan, Xie, Feng, Zhang, Lei, Zhou, Xiaoxue, Huang, Jun, Wang, Fangwei, Jin, Jin, Zhang, Long, Zeng, Linghui, Zhou, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596143/
https://www.ncbi.nlm.nih.gov/pubmed/34658167
http://dx.doi.org/10.1002/advs.202101672
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author Xie, Yifan
Xie, Feng
Zhang, Lei
Zhou, Xiaoxue
Huang, Jun
Wang, Fangwei
Jin, Jin
Zhang, Long
Zeng, Linghui
Zhou, Fangfang
author_facet Xie, Yifan
Xie, Feng
Zhang, Lei
Zhou, Xiaoxue
Huang, Jun
Wang, Fangwei
Jin, Jin
Zhang, Long
Zeng, Linghui
Zhou, Fangfang
author_sort Xie, Yifan
collection PubMed
description In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8(+) T cells, CD4(+) T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.
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spelling pubmed-85961432021-12-02 Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells Xie, Yifan Xie, Feng Zhang, Lei Zhou, Xiaoxue Huang, Jun Wang, Fangwei Jin, Jin Zhang, Long Zeng, Linghui Zhou, Fangfang Adv Sci (Weinh) Reviews In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8(+) T cells, CD4(+) T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment. John Wiley and Sons Inc. 2021-10-18 /pmc/articles/PMC8596143/ /pubmed/34658167 http://dx.doi.org/10.1002/advs.202101672 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xie, Yifan
Xie, Feng
Zhang, Lei
Zhou, Xiaoxue
Huang, Jun
Wang, Fangwei
Jin, Jin
Zhang, Long
Zeng, Linghui
Zhou, Fangfang
Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_full Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_fullStr Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_full_unstemmed Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_short Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_sort targeted anti‐tumor immunotherapy using tumor infiltrating cells
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596143/
https://www.ncbi.nlm.nih.gov/pubmed/34658167
http://dx.doi.org/10.1002/advs.202101672
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