Cargando…

A global repository of novel antimicrobial emergence events

Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Mendelsohn, Emma, Ross, Noam, White, Allison M., Whiting, Karissa, Basaraba, Cale, Watson Madubuonwu, Brooke, Johnson, Erica, Dualeh, Mushtaq, Matson, Zach, Dattaray, Sonia, Ezeokoli, Nchedochukwu, Kirshenbaum Lieberman, Melanie, Kotcher, Jacob, Maher, Samantha, Zambrana-Torrelio, Carlos, Daszak, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596184/
https://www.ncbi.nlm.nih.gov/pubmed/34909196
http://dx.doi.org/10.12688/f1000research.26870.2
_version_ 1784600305536598016
author Mendelsohn, Emma
Ross, Noam
White, Allison M.
Whiting, Karissa
Basaraba, Cale
Watson Madubuonwu, Brooke
Johnson, Erica
Dualeh, Mushtaq
Matson, Zach
Dattaray, Sonia
Ezeokoli, Nchedochukwu
Kirshenbaum Lieberman, Melanie
Kotcher, Jacob
Maher, Samantha
Zambrana-Torrelio, Carlos
Daszak, Peter
author_facet Mendelsohn, Emma
Ross, Noam
White, Allison M.
Whiting, Karissa
Basaraba, Cale
Watson Madubuonwu, Brooke
Johnson, Erica
Dualeh, Mushtaq
Matson, Zach
Dattaray, Sonia
Ezeokoli, Nchedochukwu
Kirshenbaum Lieberman, Melanie
Kotcher, Jacob
Maher, Samantha
Zambrana-Torrelio, Carlos
Daszak, Peter
author_sort Mendelsohn, Emma
collection PubMed
description Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance reports (1994-2017) to identify global events of novel AMR emergence (first clinical reports of unique drug-bacteria resistance combinations). We screened 24,966 abstracts and reports, ultimately identifying 1,757 novel AMR emergence events from 268 peer-reviewed studies and 26 disease surveillance reports (294 total). Events were reported in 66 countries, with most events in the United States (152), China (128), and India (127). The most common bacteria demonstrating new resistance were Klebsiella pneumoniae (344) and Escherichia coli (218). Resistance was most common against antibiotic drugs imipenem (89 events), ciprofloxacin (84) and ceftazidime (83). We provide an open-access database of emergence events with standardized fields for bacterial species, drugs, location, and date. We discuss the impact of reporting and surveillance bias on database coverage, and we suggest guidelines for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions.
format Online
Article
Text
id pubmed-8596184
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher F1000 Research Limited
record_format MEDLINE/PubMed
spelling pubmed-85961842021-12-13 A global repository of novel antimicrobial emergence events Mendelsohn, Emma Ross, Noam White, Allison M. Whiting, Karissa Basaraba, Cale Watson Madubuonwu, Brooke Johnson, Erica Dualeh, Mushtaq Matson, Zach Dattaray, Sonia Ezeokoli, Nchedochukwu Kirshenbaum Lieberman, Melanie Kotcher, Jacob Maher, Samantha Zambrana-Torrelio, Carlos Daszak, Peter F1000Res Data Note Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance reports (1994-2017) to identify global events of novel AMR emergence (first clinical reports of unique drug-bacteria resistance combinations). We screened 24,966 abstracts and reports, ultimately identifying 1,757 novel AMR emergence events from 268 peer-reviewed studies and 26 disease surveillance reports (294 total). Events were reported in 66 countries, with most events in the United States (152), China (128), and India (127). The most common bacteria demonstrating new resistance were Klebsiella pneumoniae (344) and Escherichia coli (218). Resistance was most common against antibiotic drugs imipenem (89 events), ciprofloxacin (84) and ceftazidime (83). We provide an open-access database of emergence events with standardized fields for bacterial species, drugs, location, and date. We discuss the impact of reporting and surveillance bias on database coverage, and we suggest guidelines for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions. F1000 Research Limited 2021-06-21 /pmc/articles/PMC8596184/ /pubmed/34909196 http://dx.doi.org/10.12688/f1000research.26870.2 Text en Copyright: © 2021 Mendelsohn E et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Data Note
Mendelsohn, Emma
Ross, Noam
White, Allison M.
Whiting, Karissa
Basaraba, Cale
Watson Madubuonwu, Brooke
Johnson, Erica
Dualeh, Mushtaq
Matson, Zach
Dattaray, Sonia
Ezeokoli, Nchedochukwu
Kirshenbaum Lieberman, Melanie
Kotcher, Jacob
Maher, Samantha
Zambrana-Torrelio, Carlos
Daszak, Peter
A global repository of novel antimicrobial emergence events
title A global repository of novel antimicrobial emergence events
title_full A global repository of novel antimicrobial emergence events
title_fullStr A global repository of novel antimicrobial emergence events
title_full_unstemmed A global repository of novel antimicrobial emergence events
title_short A global repository of novel antimicrobial emergence events
title_sort global repository of novel antimicrobial emergence events
topic Data Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596184/
https://www.ncbi.nlm.nih.gov/pubmed/34909196
http://dx.doi.org/10.12688/f1000research.26870.2
work_keys_str_mv AT mendelsohnemma aglobalrepositoryofnovelantimicrobialemergenceevents
AT rossnoam aglobalrepositoryofnovelantimicrobialemergenceevents
AT whiteallisonm aglobalrepositoryofnovelantimicrobialemergenceevents
AT whitingkarissa aglobalrepositoryofnovelantimicrobialemergenceevents
AT basarabacale aglobalrepositoryofnovelantimicrobialemergenceevents
AT watsonmadubuonwubrooke aglobalrepositoryofnovelantimicrobialemergenceevents
AT johnsonerica aglobalrepositoryofnovelantimicrobialemergenceevents
AT dualehmushtaq aglobalrepositoryofnovelantimicrobialemergenceevents
AT matsonzach aglobalrepositoryofnovelantimicrobialemergenceevents
AT dattaraysonia aglobalrepositoryofnovelantimicrobialemergenceevents
AT ezeokolinchedochukwu aglobalrepositoryofnovelantimicrobialemergenceevents
AT kirshenbaumliebermanmelanie aglobalrepositoryofnovelantimicrobialemergenceevents
AT kotcherjacob aglobalrepositoryofnovelantimicrobialemergenceevents
AT mahersamantha aglobalrepositoryofnovelantimicrobialemergenceevents
AT zambranatorreliocarlos aglobalrepositoryofnovelantimicrobialemergenceevents
AT daszakpeter aglobalrepositoryofnovelantimicrobialemergenceevents
AT mendelsohnemma globalrepositoryofnovelantimicrobialemergenceevents
AT rossnoam globalrepositoryofnovelantimicrobialemergenceevents
AT whiteallisonm globalrepositoryofnovelantimicrobialemergenceevents
AT whitingkarissa globalrepositoryofnovelantimicrobialemergenceevents
AT basarabacale globalrepositoryofnovelantimicrobialemergenceevents
AT watsonmadubuonwubrooke globalrepositoryofnovelantimicrobialemergenceevents
AT johnsonerica globalrepositoryofnovelantimicrobialemergenceevents
AT dualehmushtaq globalrepositoryofnovelantimicrobialemergenceevents
AT matsonzach globalrepositoryofnovelantimicrobialemergenceevents
AT dattaraysonia globalrepositoryofnovelantimicrobialemergenceevents
AT ezeokolinchedochukwu globalrepositoryofnovelantimicrobialemergenceevents
AT kirshenbaumliebermanmelanie globalrepositoryofnovelantimicrobialemergenceevents
AT kotcherjacob globalrepositoryofnovelantimicrobialemergenceevents
AT mahersamantha globalrepositoryofnovelantimicrobialemergenceevents
AT zambranatorreliocarlos globalrepositoryofnovelantimicrobialemergenceevents
AT daszakpeter globalrepositoryofnovelantimicrobialemergenceevents