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Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis
BACKGROUND: Gastroparesis is a debilitating condition that may impact morbidity and mortality, but there is a lack of long-term studies examining this relation. The aim of this study was to determine the predictors of mortality in gastroparesis and to determine the nutritional deficiencies. METHODS:...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hellenic Society of Gastroenterology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596206/ https://www.ncbi.nlm.nih.gov/pubmed/34815644 http://dx.doi.org/10.20524/aog.2021.0660 |
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author | Amjad, Waseem Qureshi, Waqas Singh, Ritu R. Richter, Seth |
author_facet | Amjad, Waseem Qureshi, Waqas Singh, Ritu R. Richter, Seth |
author_sort | Amjad, Waseem |
collection | PubMed |
description | BACKGROUND: Gastroparesis is a debilitating condition that may impact morbidity and mortality, but there is a lack of long-term studies examining this relation. The aim of this study was to determine the predictors of mortality in gastroparesis and to determine the nutritional deficiencies. METHODS: Between September 30, 2009 and January 31, 2020, we identified 320 patients (mean age 47.5±5.3 years, 70% female, 71.3% Whites, 39.7% diabetic and 60.3% nondiabetic) with gastroparesis. (99m)Tc sulfur-labeled food was used to diagnose gastroparesis. Cox proportional-hazard regression was used to compute the association of mortality predictors. RESULTS: Of the 320 patients, 46 (14.4%) died during the study period. Among diabetics, advanced age (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.03-1.10; P<0.001), chronic kidney disease (CKD) (HR 4.69, 95%CI 1.62-13.59; P=0.004), and malnutrition (HR 10.95, 95%CI 3.23-37.17; P<0.001) were associated with higher mortality, whereas in nondiabetics older age (HR 1.05, 95%CI 1.01-1.09; P=0.04), CKD (HR 10.2, 95%CI 2.48-41.99; P=0.001), chronic obstructive pulmonary disease (COPD) (HR 7.5, 95%CI 2.11-26.82; P=0.002), coronary artery disease (CAD) (HR 9.7, 95%CI 1.8-52.21; P=0.008), and malnutrition (HR 3.83, 95%CI 1.14-29.07; P=0.03) were associated with increased mortality. Overall, 48.8% had vitamin D, 18.2% had vitamin B12, and 50.8% had iron deficiencies. Only 19.4% of the whole cohort was evaluated by a nutritionist. CONCLUSIONS: Advanced age, CAD, CKD, COPD and malnutrition were associated with higher mortality in gastroparesis. Despite the high prevalence of nutritional deficiencies, consultation of a specialist nutritionist was uncommon. |
format | Online Article Text |
id | pubmed-8596206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85962062021-11-22 Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis Amjad, Waseem Qureshi, Waqas Singh, Ritu R. Richter, Seth Ann Gastroenterol Original Article BACKGROUND: Gastroparesis is a debilitating condition that may impact morbidity and mortality, but there is a lack of long-term studies examining this relation. The aim of this study was to determine the predictors of mortality in gastroparesis and to determine the nutritional deficiencies. METHODS: Between September 30, 2009 and January 31, 2020, we identified 320 patients (mean age 47.5±5.3 years, 70% female, 71.3% Whites, 39.7% diabetic and 60.3% nondiabetic) with gastroparesis. (99m)Tc sulfur-labeled food was used to diagnose gastroparesis. Cox proportional-hazard regression was used to compute the association of mortality predictors. RESULTS: Of the 320 patients, 46 (14.4%) died during the study period. Among diabetics, advanced age (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.03-1.10; P<0.001), chronic kidney disease (CKD) (HR 4.69, 95%CI 1.62-13.59; P=0.004), and malnutrition (HR 10.95, 95%CI 3.23-37.17; P<0.001) were associated with higher mortality, whereas in nondiabetics older age (HR 1.05, 95%CI 1.01-1.09; P=0.04), CKD (HR 10.2, 95%CI 2.48-41.99; P=0.001), chronic obstructive pulmonary disease (COPD) (HR 7.5, 95%CI 2.11-26.82; P=0.002), coronary artery disease (CAD) (HR 9.7, 95%CI 1.8-52.21; P=0.008), and malnutrition (HR 3.83, 95%CI 1.14-29.07; P=0.03) were associated with increased mortality. Overall, 48.8% had vitamin D, 18.2% had vitamin B12, and 50.8% had iron deficiencies. Only 19.4% of the whole cohort was evaluated by a nutritionist. CONCLUSIONS: Advanced age, CAD, CKD, COPD and malnutrition were associated with higher mortality in gastroparesis. Despite the high prevalence of nutritional deficiencies, consultation of a specialist nutritionist was uncommon. Hellenic Society of Gastroenterology 2021 2021-09-14 /pmc/articles/PMC8596206/ /pubmed/34815644 http://dx.doi.org/10.20524/aog.2021.0660 Text en Copyright: © Hellenic Society of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Amjad, Waseem Qureshi, Waqas Singh, Ritu R. Richter, Seth Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title_full | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title_fullStr | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title_full_unstemmed | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title_short | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
title_sort | nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596206/ https://www.ncbi.nlm.nih.gov/pubmed/34815644 http://dx.doi.org/10.20524/aog.2021.0660 |
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