Cargando…
Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
BACKGROUND: The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596349/ https://www.ncbi.nlm.nih.gov/pubmed/34805533 http://dx.doi.org/10.1186/s41231-021-00106-0 |
_version_ | 1784600342618439680 |
---|---|
author | Kouhpayeh, Hamid Reza Tabasi, Farhad Dehvari, Mohammad Naderi, Mohammad Bahari, Gholamreza Khalili, Tahereh Clark, Courtney Ghavami, Saeid Taheri, Mohsen |
author_facet | Kouhpayeh, Hamid Reza Tabasi, Farhad Dehvari, Mohammad Naderi, Mohammad Bahari, Gholamreza Khalili, Tahereh Clark, Courtney Ghavami, Saeid Taheri, Mohsen |
author_sort | Kouhpayeh, Hamid Reza |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the renin-angiotensin system (RAS) balance alter an individual’s susceptibility to COVID-19 infection. We aimed to evaluate the association between AGT rs699 C > T, ACE rs4646994 I/D, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection and the severity in a sample of the southeast Iranian population. METHODS: A total of 504 subjects, including 258 COVID-19 positives, and 246 healthy controls, were recruited. Genotyping of the ACE gene rs4646994, and AGT rs699, and AGTR1 rs5186 polymorphisms was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP), respectively. RESULTS: Our results showed that the II genotype of ACE rs4646994 and the I allele decreased the risk of COVID-19 infection. Moreover, we found that the TC genotype and C allele of AGT rs699 increased the risk of COVID-19 infection. The AGTR1 rs5186 was not associated with COVID-19 infection. Also, we did not find any association between these polymorphisms and the severity of the disease. However, we found a significantly higher age and prevalence of diabetes and hypertension in patients with severe disease than a non-severe disease. CONCLUSIONS: These findings suggest that ACE rs4646994 and AGT rs699 polymorphisms increase the risk of COVID-19 infection in a southeast Iranian population. |
format | Online Article Text |
id | pubmed-8596349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85963492021-11-17 Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study Kouhpayeh, Hamid Reza Tabasi, Farhad Dehvari, Mohammad Naderi, Mohammad Bahari, Gholamreza Khalili, Tahereh Clark, Courtney Ghavami, Saeid Taheri, Mohsen Transl Med Commun Research BACKGROUND: The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the renin-angiotensin system (RAS) balance alter an individual’s susceptibility to COVID-19 infection. We aimed to evaluate the association between AGT rs699 C > T, ACE rs4646994 I/D, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection and the severity in a sample of the southeast Iranian population. METHODS: A total of 504 subjects, including 258 COVID-19 positives, and 246 healthy controls, were recruited. Genotyping of the ACE gene rs4646994, and AGT rs699, and AGTR1 rs5186 polymorphisms was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP), respectively. RESULTS: Our results showed that the II genotype of ACE rs4646994 and the I allele decreased the risk of COVID-19 infection. Moreover, we found that the TC genotype and C allele of AGT rs699 increased the risk of COVID-19 infection. The AGTR1 rs5186 was not associated with COVID-19 infection. Also, we did not find any association between these polymorphisms and the severity of the disease. However, we found a significantly higher age and prevalence of diabetes and hypertension in patients with severe disease than a non-severe disease. CONCLUSIONS: These findings suggest that ACE rs4646994 and AGT rs699 polymorphisms increase the risk of COVID-19 infection in a southeast Iranian population. BioMed Central 2021-11-17 2021 /pmc/articles/PMC8596349/ /pubmed/34805533 http://dx.doi.org/10.1186/s41231-021-00106-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Kouhpayeh, Hamid Reza Tabasi, Farhad Dehvari, Mohammad Naderi, Mohammad Bahari, Gholamreza Khalili, Tahereh Clark, Courtney Ghavami, Saeid Taheri, Mohsen Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title | Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title_full | Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title_fullStr | Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title_full_unstemmed | Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title_short | Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study |
title_sort | association between angiotensinogen (agt), angiotensin-converting enzyme (ace) and angiotensin-ii receptor 1 (agtr1) polymorphisms and covid-19 infection in the southeast of iran: a preliminary case-control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596349/ https://www.ncbi.nlm.nih.gov/pubmed/34805533 http://dx.doi.org/10.1186/s41231-021-00106-0 |
work_keys_str_mv | AT kouhpayehhamidreza associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT tabasifarhad associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT dehvarimohammad associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT naderimohammad associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT baharigholamreza associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT khalilitahereh associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT clarkcourtney associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT ghavamisaeid associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy AT taherimohsen associationbetweenangiotensinogenagtangiotensinconvertingenzymeaceandangiotensiniireceptor1agtr1polymorphismsandcovid19infectioninthesoutheastofiranapreliminarycasecontrolstudy |