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A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596411/ https://www.ncbi.nlm.nih.gov/pubmed/34130356 http://dx.doi.org/10.1002/gps.5588 |
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author | Oude Voshaar, Richard C. Dimitriadis, Menelaos vandenBrink, Rob H. S. Aprahamian, Ivan Borges, Marcus K. Marijnissen, Radboud M. Hoogendijk, Emiel O. Rhebergen, Didi Jeuring, Hans W. |
author_facet | Oude Voshaar, Richard C. Dimitriadis, Menelaos vandenBrink, Rob H. S. Aprahamian, Ivan Borges, Marcus K. Marijnissen, Radboud M. Hoogendijk, Emiel O. Rhebergen, Didi Jeuring, Hans W. |
author_sort | Oude Voshaar, Richard C. |
collection | PubMed |
description | INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. METHODS: A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients with a DSM‐IV‐defined depressive disorder and 132 never‐depressed controls. Site visits at baseline, 2 and 6‐year follow‐up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41‐item FI was operationalised and validated against the 6‐year morality rate by Cox regression (HR(FI) = 1.04 [95% CI: 1.02–1.06]). RESULTS: Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR(FI) = 0.98 [95% CI: 0.97–0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. CONCLUSIONS: The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM‐IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late‐life depression. |
format | Online Article Text |
id | pubmed-8596411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85964112021-11-22 A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder Oude Voshaar, Richard C. Dimitriadis, Menelaos vandenBrink, Rob H. S. Aprahamian, Ivan Borges, Marcus K. Marijnissen, Radboud M. Hoogendijk, Emiel O. Rhebergen, Didi Jeuring, Hans W. Int J Geriatr Psychiatry Research Articles INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. METHODS: A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients with a DSM‐IV‐defined depressive disorder and 132 never‐depressed controls. Site visits at baseline, 2 and 6‐year follow‐up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41‐item FI was operationalised and validated against the 6‐year morality rate by Cox regression (HR(FI) = 1.04 [95% CI: 1.02–1.06]). RESULTS: Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR(FI) = 0.98 [95% CI: 0.97–0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. CONCLUSIONS: The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM‐IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late‐life depression. John Wiley and Sons Inc. 2021-06-19 2021-11 /pmc/articles/PMC8596411/ /pubmed/34130356 http://dx.doi.org/10.1002/gps.5588 Text en © 2021 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Oude Voshaar, Richard C. Dimitriadis, Menelaos vandenBrink, Rob H. S. Aprahamian, Ivan Borges, Marcus K. Marijnissen, Radboud M. Hoogendijk, Emiel O. Rhebergen, Didi Jeuring, Hans W. A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title | A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title_full | A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title_fullStr | A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title_full_unstemmed | A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title_short | A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
title_sort | 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596411/ https://www.ncbi.nlm.nih.gov/pubmed/34130356 http://dx.doi.org/10.1002/gps.5588 |
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