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A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive...

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Autores principales: Oude Voshaar, Richard C., Dimitriadis, Menelaos, vandenBrink, Rob H. S., Aprahamian, Ivan, Borges, Marcus K., Marijnissen, Radboud M., Hoogendijk, Emiel O., Rhebergen, Didi, Jeuring, Hans W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596411/
https://www.ncbi.nlm.nih.gov/pubmed/34130356
http://dx.doi.org/10.1002/gps.5588
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author Oude Voshaar, Richard C.
Dimitriadis, Menelaos
vandenBrink, Rob H. S.
Aprahamian, Ivan
Borges, Marcus K.
Marijnissen, Radboud M.
Hoogendijk, Emiel O.
Rhebergen, Didi
Jeuring, Hans W.
author_facet Oude Voshaar, Richard C.
Dimitriadis, Menelaos
vandenBrink, Rob H. S.
Aprahamian, Ivan
Borges, Marcus K.
Marijnissen, Radboud M.
Hoogendijk, Emiel O.
Rhebergen, Didi
Jeuring, Hans W.
author_sort Oude Voshaar, Richard C.
collection PubMed
description INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. METHODS: A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients with a DSM‐IV‐defined depressive disorder and 132 never‐depressed controls. Site visits at baseline, 2 and 6‐year follow‐up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41‐item FI was operationalised and validated against the 6‐year morality rate by Cox regression (HR(FI) = 1.04 [95% CI: 1.02–1.06]). RESULTS: Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR(FI) = 0.98 [95% CI: 0.97–0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. CONCLUSIONS: The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM‐IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late‐life depression.
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spelling pubmed-85964112021-11-22 A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder Oude Voshaar, Richard C. Dimitriadis, Menelaos vandenBrink, Rob H. S. Aprahamian, Ivan Borges, Marcus K. Marijnissen, Radboud M. Hoogendijk, Emiel O. Rhebergen, Didi Jeuring, Hans W. Int J Geriatr Psychiatry Research Articles INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. METHODS: A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients with a DSM‐IV‐defined depressive disorder and 132 never‐depressed controls. Site visits at baseline, 2 and 6‐year follow‐up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41‐item FI was operationalised and validated against the 6‐year morality rate by Cox regression (HR(FI) = 1.04 [95% CI: 1.02–1.06]). RESULTS: Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR(FI) = 0.98 [95% CI: 0.97–0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. CONCLUSIONS: The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM‐IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late‐life depression. John Wiley and Sons Inc. 2021-06-19 2021-11 /pmc/articles/PMC8596411/ /pubmed/34130356 http://dx.doi.org/10.1002/gps.5588 Text en © 2021 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Oude Voshaar, Richard C.
Dimitriadis, Menelaos
vandenBrink, Rob H. S.
Aprahamian, Ivan
Borges, Marcus K.
Marijnissen, Radboud M.
Hoogendijk, Emiel O.
Rhebergen, Didi
Jeuring, Hans W.
A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title_full A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title_fullStr A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title_full_unstemmed A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title_short A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
title_sort 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596411/
https://www.ncbi.nlm.nih.gov/pubmed/34130356
http://dx.doi.org/10.1002/gps.5588
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