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Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2

We developed an intranasal vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using the replication-incompetent human parainfluenza virus type 2 (hPIV2) vector BC-PIV, which can deliver ectopic gene as stable RNA and ectopic protein on the envelope. BC-PIV expressing the fu...

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Detalles Bibliográficos
Autores principales:	Ohtsuka, Junpei, Imai, Masaki, Fukumura, Masayuki, Maeda, Mitsuyo, Eguchi, Asami, Ono, Ryoichi, Maemura, Tadashi, Ito, Mutsumi, Yamayoshi, Seiya, Kataoka, Yosky, Kawaoka, Yoshihiro, Nosaka, Tetsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596570/ https://www.ncbi.nlm.nih.gov/pubmed/34805782 http://dx.doi.org/10.1016/j.isci.2021.103379

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