High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva

We report a simple and rapid saliva‐based SARS‐CoV‐2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically recognizes the spike proteins of the wildtype virus and its Alpha and Delta variants with dissociation constants of 120, 290 and 480 pM, respect...

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Detalles Bibliográficos
Autores principales: Zhang, Zijie, Pandey, Richa, Li, Jiuxing, Gu, Jimmy, White, Dawn, Stacey, Hannah D., Ang, Jann C., Steinberg, Catherine‐Jean, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Balion, Cynthia, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Soleymani, Leyla, Brennan, John D., Li, Yingfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596624/
https://www.ncbi.nlm.nih.gov/pubmed/34464491
http://dx.doi.org/10.1002/anie.202110819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596624/
https://www.ncbi.nlm.nih.gov/pubmed/34464491
http://dx.doi.org/10.1002/anie.202110819

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