Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran

A mild, facile, and environmentally friendly electrochemical protocol for the C(sp(3))−H/O−H cross dehydrogenative coupling between various alcohols and tetrahydrofuran with H(2) evolution is herein reported. This synthetic strategy does not require external oxidants nor catalysts. The broad functio...

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Detalles Bibliográficos
Autores principales: Huang, Raolin, Yu, Congjun, Patureau, Frederic W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596688/
https://www.ncbi.nlm.nih.gov/pubmed/34820252
http://dx.doi.org/10.1002/celc.202101155
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author Huang, Raolin
Yu, Congjun
Patureau, Frederic W.
author_facet Huang, Raolin
Yu, Congjun
Patureau, Frederic W.
author_sort Huang, Raolin
collection PubMed
description A mild, facile, and environmentally friendly electrochemical protocol for the C(sp(3))−H/O−H cross dehydrogenative coupling between various alcohols and tetrahydrofuran with H(2) evolution is herein reported. This synthetic strategy does not require external oxidants nor catalysts. The broad functional group compatibility includes hydroxyl, halogens, olefins as well as an alkyne. Initial mechanistic investigations were conducted. The method provides a green and efficient hydroxyl group protection.
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spelling pubmed-85966882021-11-22 Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran Huang, Raolin Yu, Congjun Patureau, Frederic W. ChemElectroChem Communications A mild, facile, and environmentally friendly electrochemical protocol for the C(sp(3))−H/O−H cross dehydrogenative coupling between various alcohols and tetrahydrofuran with H(2) evolution is herein reported. This synthetic strategy does not require external oxidants nor catalysts. The broad functional group compatibility includes hydroxyl, halogens, olefins as well as an alkyne. Initial mechanistic investigations were conducted. The method provides a green and efficient hydroxyl group protection. John Wiley and Sons Inc. 2021-10-21 2021-10-13 /pmc/articles/PMC8596688/ /pubmed/34820252 http://dx.doi.org/10.1002/celc.202101155 Text en © 2021 The Authors. ChemElectroChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Huang, Raolin
Yu, Congjun
Patureau, Frederic W.
Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title_full Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title_fullStr Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title_full_unstemmed Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title_short Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
title_sort electrochemical dehydrogenative acetalization protection of alcohols with tetrahydrofuran
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596688/
https://www.ncbi.nlm.nih.gov/pubmed/34820252
http://dx.doi.org/10.1002/celc.202101155
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AT yucongjun electrochemicaldehydrogenativeacetalizationprotectionofalcoholswithtetrahydrofuran
AT patureaufredericw electrochemicaldehydrogenativeacetalizationprotectionofalcoholswithtetrahydrofuran

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