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Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina

INTRODUCTION: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness. AIM: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigat...

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Autores principales: Kurzelowski, Radosław, Barański, Kamil, Caluori, Guido, Szot, Wojciech, Grabowski, Krzysztof, Michalewska-Włudarczyk, Aleksandra, Syzdół, Marcin, Kuczmik, Wacław, Błach, Anna, Ochała, Beata, Hudziak, Damian, Wilczek, Jacek, Gołba, Krzysztof S., Starek, Zdenek, Tendera, Michał, Wojakowski, Wojciech, Jadczyk, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596713/
https://www.ncbi.nlm.nih.gov/pubmed/34819964
http://dx.doi.org/10.5114/aic.2021.109168
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author Kurzelowski, Radosław
Barański, Kamil
Caluori, Guido
Szot, Wojciech
Grabowski, Krzysztof
Michalewska-Włudarczyk, Aleksandra
Syzdół, Marcin
Kuczmik, Wacław
Błach, Anna
Ochała, Beata
Hudziak, Damian
Wilczek, Jacek
Gołba, Krzysztof S.
Starek, Zdenek
Tendera, Michał
Wojakowski, Wojciech
Jadczyk, Tomasz
author_facet Kurzelowski, Radosław
Barański, Kamil
Caluori, Guido
Szot, Wojciech
Grabowski, Krzysztof
Michalewska-Włudarczyk, Aleksandra
Syzdół, Marcin
Kuczmik, Wacław
Błach, Anna
Ochała, Beata
Hudziak, Damian
Wilczek, Jacek
Gołba, Krzysztof S.
Starek, Zdenek
Tendera, Michał
Wojakowski, Wojciech
Jadczyk, Tomasz
author_sort Kurzelowski, Radosław
collection PubMed
description INTRODUCTION: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness. AIM: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigation of correlation between EM parameters of the myocardium and response to CD133+ cell therapy. MATERIAL AND METHODS: Thirty patients with RFA (16 active and 14 placebo individuals) enrolled in the REGENT-VSEL trial underwent EM evaluation of the LV with intracardiac mapping system. The following parameters were analyzed: unipolar voltage (UV), bipolar voltage (BV), local linear shortening (LLS). Myocardial ischemia was evaluated with single-photon emission computed tomography (SPECT). The median value of each EM parameter was used for intra-group comparisons. RESULTS: Global EM parameters (UV, BV, LLS) of LV in active and placebo groups were 11.28 mV, 3.58 mV, 11.12%, respectively; 13.00 mV, 3.81 mV, 11.32%, respectively. EM characteristics analyzed at global and segmental levels did not predict response to CD133+ cell therapy in patients with RFA (Global UV, BV and LLS at rest R = –0.06; R = 0.2; R = –0.1 and at stress: R = 0.07, R = 0.09, R = –0.1, respectively; Segmental UV, BV, LLS at rest R = –0.2, R = 0.03, R = –0.4 and at stress R = 0.02, R = 0.2, R = –0.2, respectively). Multiple linear regression of the treated segments showed that only pre-injection SPECT levels were significantly correlated with post-injection SPECT, either at rest or stress (p < 0.05). CONCLUSIONS: Electromechanical characteristics of the left ventricle do not predict changes of myocardial perfusion by SPECT after cell therapy. Baseline SPECT results are only predictors of changes of myocardial ischemia observed at 4-month follow-up.
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spelling pubmed-85967132021-11-23 Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina Kurzelowski, Radosław Barański, Kamil Caluori, Guido Szot, Wojciech Grabowski, Krzysztof Michalewska-Włudarczyk, Aleksandra Syzdół, Marcin Kuczmik, Wacław Błach, Anna Ochała, Beata Hudziak, Damian Wilczek, Jacek Gołba, Krzysztof S. Starek, Zdenek Tendera, Michał Wojakowski, Wojciech Jadczyk, Tomasz Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness. AIM: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigation of correlation between EM parameters of the myocardium and response to CD133+ cell therapy. MATERIAL AND METHODS: Thirty patients with RFA (16 active and 14 placebo individuals) enrolled in the REGENT-VSEL trial underwent EM evaluation of the LV with intracardiac mapping system. The following parameters were analyzed: unipolar voltage (UV), bipolar voltage (BV), local linear shortening (LLS). Myocardial ischemia was evaluated with single-photon emission computed tomography (SPECT). The median value of each EM parameter was used for intra-group comparisons. RESULTS: Global EM parameters (UV, BV, LLS) of LV in active and placebo groups were 11.28 mV, 3.58 mV, 11.12%, respectively; 13.00 mV, 3.81 mV, 11.32%, respectively. EM characteristics analyzed at global and segmental levels did not predict response to CD133+ cell therapy in patients with RFA (Global UV, BV and LLS at rest R = –0.06; R = 0.2; R = –0.1 and at stress: R = 0.07, R = 0.09, R = –0.1, respectively; Segmental UV, BV, LLS at rest R = –0.2, R = 0.03, R = –0.4 and at stress R = 0.02, R = 0.2, R = –0.2, respectively). Multiple linear regression of the treated segments showed that only pre-injection SPECT levels were significantly correlated with post-injection SPECT, either at rest or stress (p < 0.05). CONCLUSIONS: Electromechanical characteristics of the left ventricle do not predict changes of myocardial perfusion by SPECT after cell therapy. Baseline SPECT results are only predictors of changes of myocardial ischemia observed at 4-month follow-up. Termedia Publishing House 2021-09-14 2021-09 /pmc/articles/PMC8596713/ /pubmed/34819964 http://dx.doi.org/10.5114/aic.2021.109168 Text en Copyright: © 2021 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Kurzelowski, Radosław
Barański, Kamil
Caluori, Guido
Szot, Wojciech
Grabowski, Krzysztof
Michalewska-Włudarczyk, Aleksandra
Syzdół, Marcin
Kuczmik, Wacław
Błach, Anna
Ochała, Beata
Hudziak, Damian
Wilczek, Jacek
Gołba, Krzysztof S.
Starek, Zdenek
Tendera, Michał
Wojakowski, Wojciech
Jadczyk, Tomasz
Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title_full Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title_fullStr Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title_full_unstemmed Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title_short Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina
title_sort correlation between electromechanical parameters (noga xp) and changes of myocardial ischemia in patients with refractory angina
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596713/
https://www.ncbi.nlm.nih.gov/pubmed/34819964
http://dx.doi.org/10.5114/aic.2021.109168
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