Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M(1)‐acetylcholine receptor agonist: A randomized cross‐over trial

AIMS: HTL0009936 is a selective M(1) muscarinic receptor agonist in development for cognitive dysfunction in Alzheimer's disease. Safety, tolerability and pharmacokinetics and exploratory pharmacodynamic effects of HTL0009936 administered by continuous IV infusion at steady state were investiga...

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Detalles Bibliográficos
Autores principales: Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Stevens, Jasper, Cross, David M., Tasker, Tim, Nathan, Pradeep J., Groeneveld, Geert Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596821/
https://www.ncbi.nlm.nih.gov/pubmed/33891333
http://dx.doi.org/10.1111/bcp.14872

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