Cargando…
Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis
OBJECTIVE: To investigate the two‐year course of pain and osteoarthritic features on magnetic resonance imaging (MRI) in the thumb base. METHODS: Patients in the Hand Osteoarthritis in Secondary Care (HOSTAS) cohort who had received radiographic examination, MRI, and clinical examination of the righ...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596842/ https://www.ncbi.nlm.nih.gov/pubmed/32558377 http://dx.doi.org/10.1002/acr.24355 |
_version_ | 1784600478477189120 |
---|---|
author | van Beest, Sjoerd Kroon, Herman M. Reijnierse, Monique Rosendaal, Frits R. Kloppenburg, Margreet Kroon, Féline P. B. |
author_facet | van Beest, Sjoerd Kroon, Herman M. Reijnierse, Monique Rosendaal, Frits R. Kloppenburg, Margreet Kroon, Féline P. B. |
author_sort | van Beest, Sjoerd |
collection | PubMed |
description | OBJECTIVE: To investigate the two‐year course of pain and osteoarthritic features on magnetic resonance imaging (MRI) in the thumb base. METHODS: Patients in the Hand Osteoarthritis in Secondary Care (HOSTAS) cohort who had received radiographic examination, MRI, and clinical examination of the right thumb base at baseline and who had a 2‐year follow‐up period were studied. Pain on palpation of the thumb base was assessed on a 0–3 scale. MRIs were analyzed with the Outcome Measures in Rheumatology (OMERACT) thumb base osteoarthritis MRI scoring system for synovitis, bone marrow lesions (BMLs), subchondral bone defects, cartilage space loss, osteophytes, and subluxation. Radiographs were assessed for osteophytes and joint space narrowing. We studied the associations of changes in synovitis and BMLs with changes in pain using a logistic regression model adjusted for radiographic damage, with values expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Of 165 patients, 83% were women and the mean age was 60.7 years. At baseline, 65 patients had thumb base pain. At 2‐year follow‐up, pain had decreased in 32 patients and increased in 33 patients. MRI features remained stable in most patients. Structural MRI features generally deteriorated, while synovitis and BMLs improved in some individuals and deteriorated in others. Change in radiographic osteophytes rarely occurred (n = 10). Increased synovitis (odds ratio [OR] 3.4 [95% CI 1.3–9.3]) and increased BMLs (OR 5.1 [95% CI 2.1–12.6]) were associated with increased pain. Decreased BMLs appeared to be associated with decreased pain (OR 2.7 [95% CI 0.8–8.9]), and reductions in synovitis occurred too infrequently to calculate associations. CONCLUSION: Over 2 years, thumb base pain fluctuated, while MRI features changed in a minority of patients with hand osteoarthritis. Changes in synovitis and BMLs were associated with changes in pain on palpation, even after adjustment for radiographic damage. |
format | Online Article Text |
id | pubmed-8596842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85968422021-11-22 Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis van Beest, Sjoerd Kroon, Herman M. Reijnierse, Monique Rosendaal, Frits R. Kloppenburg, Margreet Kroon, Féline P. B. Arthritis Care Res (Hoboken) Osteoarthritis OBJECTIVE: To investigate the two‐year course of pain and osteoarthritic features on magnetic resonance imaging (MRI) in the thumb base. METHODS: Patients in the Hand Osteoarthritis in Secondary Care (HOSTAS) cohort who had received radiographic examination, MRI, and clinical examination of the right thumb base at baseline and who had a 2‐year follow‐up period were studied. Pain on palpation of the thumb base was assessed on a 0–3 scale. MRIs were analyzed with the Outcome Measures in Rheumatology (OMERACT) thumb base osteoarthritis MRI scoring system for synovitis, bone marrow lesions (BMLs), subchondral bone defects, cartilage space loss, osteophytes, and subluxation. Radiographs were assessed for osteophytes and joint space narrowing. We studied the associations of changes in synovitis and BMLs with changes in pain using a logistic regression model adjusted for radiographic damage, with values expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Of 165 patients, 83% were women and the mean age was 60.7 years. At baseline, 65 patients had thumb base pain. At 2‐year follow‐up, pain had decreased in 32 patients and increased in 33 patients. MRI features remained stable in most patients. Structural MRI features generally deteriorated, while synovitis and BMLs improved in some individuals and deteriorated in others. Change in radiographic osteophytes rarely occurred (n = 10). Increased synovitis (odds ratio [OR] 3.4 [95% CI 1.3–9.3]) and increased BMLs (OR 5.1 [95% CI 2.1–12.6]) were associated with increased pain. Decreased BMLs appeared to be associated with decreased pain (OR 2.7 [95% CI 0.8–8.9]), and reductions in synovitis occurred too infrequently to calculate associations. CONCLUSION: Over 2 years, thumb base pain fluctuated, while MRI features changed in a minority of patients with hand osteoarthritis. Changes in synovitis and BMLs were associated with changes in pain on palpation, even after adjustment for radiographic damage. John Wiley and Sons Inc. 2021-10-04 2021-11 /pmc/articles/PMC8596842/ /pubmed/32558377 http://dx.doi.org/10.1002/acr.24355 Text en © 2020 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Osteoarthritis van Beest, Sjoerd Kroon, Herman M. Reijnierse, Monique Rosendaal, Frits R. Kloppenburg, Margreet Kroon, Féline P. B. Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title | Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title_full | Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title_fullStr | Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title_full_unstemmed | Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title_short | Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis |
title_sort | two‐year changes in magnetic resonance imaging features and pain in thumb base osteoarthritis |
topic | Osteoarthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596842/ https://www.ncbi.nlm.nih.gov/pubmed/32558377 http://dx.doi.org/10.1002/acr.24355 |
work_keys_str_mv | AT vanbeestsjoerd twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis AT kroonhermanm twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis AT reijniersemonique twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis AT rosendaalfritsr twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis AT kloppenburgmargreet twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis AT kroonfelinepb twoyearchangesinmagneticresonanceimagingfeaturesandpaininthumbbaseosteoarthritis |