Decarboxylative Hydroxylation of Benzoic Acids

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand‐to‐metal charge transfer (LMCT)‐enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild c...

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Detalles Bibliográficos
Autores principales: Su, Wanqi, Xu, Peng, Ritter, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596882/
https://www.ncbi.nlm.nih.gov/pubmed/34464007
http://dx.doi.org/10.1002/anie.202108971
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author Su, Wanqi
Xu, Peng
Ritter, Tobias
author_facet Su, Wanqi
Xu, Peng
Ritter, Tobias
author_sort Su, Wanqi
collection PubMed
description Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand‐to‐metal charge transfer (LMCT)‐enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late‐stage applications.
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spelling pubmed-85968822021-11-22 Decarboxylative Hydroxylation of Benzoic Acids Su, Wanqi Xu, Peng Ritter, Tobias Angew Chem Int Ed Engl Communications Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand‐to‐metal charge transfer (LMCT)‐enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late‐stage applications. John Wiley and Sons Inc. 2021-10-04 2021-11-02 /pmc/articles/PMC8596882/ /pubmed/34464007 http://dx.doi.org/10.1002/anie.202108971 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Su, Wanqi
Xu, Peng
Ritter, Tobias
Decarboxylative Hydroxylation of Benzoic Acids
title Decarboxylative Hydroxylation of Benzoic Acids
title_full Decarboxylative Hydroxylation of Benzoic Acids
title_fullStr Decarboxylative Hydroxylation of Benzoic Acids
title_full_unstemmed Decarboxylative Hydroxylation of Benzoic Acids
title_short Decarboxylative Hydroxylation of Benzoic Acids
title_sort decarboxylative hydroxylation of benzoic acids
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596882/
https://www.ncbi.nlm.nih.gov/pubmed/34464007
http://dx.doi.org/10.1002/anie.202108971
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AT xupeng decarboxylativehydroxylationofbenzoicacids
AT rittertobias decarboxylativehydroxylationofbenzoicacids

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