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Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex

It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neura...

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Autores principales: Takeuchi, Hikaru, Kimura, Ryosuke, Tomita, Hiroaki, Taki, Yasuyuki, Kikuchi, Yoshie, Ono, Chiaki, Yu, Zhiqian, Matsudaira, Izumi, Nouchi, Rui, Yokoyama, Ryoichi, Kotozaki, Yuka, Nakagawa, Seishu, Hanawa, Sugiko, Iizuka, Kunio, Sekiguchi, Atsushi, Araki, Tsuyoshi, Miyauchi, Carlos Makoto, Ikeda, Shigeyuki, Sakaki, Kohei, dos S. Kawata, Kelssy H., Nozawa, Takayuki, Yokota, Susumu, Magistro, Daniele, Imanishi, Tadashi, Kawashima, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596941/
https://www.ncbi.nlm.nih.gov/pubmed/34587347
http://dx.doi.org/10.1002/hbm.25667
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author Takeuchi, Hikaru
Kimura, Ryosuke
Tomita, Hiroaki
Taki, Yasuyuki
Kikuchi, Yoshie
Ono, Chiaki
Yu, Zhiqian
Matsudaira, Izumi
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Hanawa, Sugiko
Iizuka, Kunio
Sekiguchi, Atsushi
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Ikeda, Shigeyuki
Sakaki, Kohei
dos S. Kawata, Kelssy H.
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Imanishi, Tadashi
Kawashima, Ryuta
author_facet Takeuchi, Hikaru
Kimura, Ryosuke
Tomita, Hiroaki
Taki, Yasuyuki
Kikuchi, Yoshie
Ono, Chiaki
Yu, Zhiqian
Matsudaira, Izumi
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Hanawa, Sugiko
Iizuka, Kunio
Sekiguchi, Atsushi
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Ikeda, Shigeyuki
Sakaki, Kohei
dos S. Kawata, Kelssy H.
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Imanishi, Tadashi
Kawashima, Ryuta
author_sort Takeuchi, Hikaru
collection PubMed
description It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD‐PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole‐brain voxel‐by‐voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD‐PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD‐PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD‐PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
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spelling pubmed-85969412021-12-02 Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex Takeuchi, Hikaru Kimura, Ryosuke Tomita, Hiroaki Taki, Yasuyuki Kikuchi, Yoshie Ono, Chiaki Yu, Zhiqian Matsudaira, Izumi Nouchi, Rui Yokoyama, Ryoichi Kotozaki, Yuka Nakagawa, Seishu Hanawa, Sugiko Iizuka, Kunio Sekiguchi, Atsushi Araki, Tsuyoshi Miyauchi, Carlos Makoto Ikeda, Shigeyuki Sakaki, Kohei dos S. Kawata, Kelssy H. Nozawa, Takayuki Yokota, Susumu Magistro, Daniele Imanishi, Tadashi Kawashima, Ryuta Hum Brain Mapp Research Articles It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD‐PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole‐brain voxel‐by‐voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD‐PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD‐PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD‐PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals. John Wiley & Sons, Inc. 2021-09-29 /pmc/articles/PMC8596941/ /pubmed/34587347 http://dx.doi.org/10.1002/hbm.25667 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Takeuchi, Hikaru
Kimura, Ryosuke
Tomita, Hiroaki
Taki, Yasuyuki
Kikuchi, Yoshie
Ono, Chiaki
Yu, Zhiqian
Matsudaira, Izumi
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Hanawa, Sugiko
Iizuka, Kunio
Sekiguchi, Atsushi
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Ikeda, Shigeyuki
Sakaki, Kohei
dos S. Kawata, Kelssy H.
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Imanishi, Tadashi
Kawashima, Ryuta
Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title_full Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title_fullStr Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title_full_unstemmed Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title_short Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
title_sort polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596941/
https://www.ncbi.nlm.nih.gov/pubmed/34587347
http://dx.doi.org/10.1002/hbm.25667
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