Histological and immunohistochemical changes in facial skin treated with combined ablative and non‐ablative laser therapy

BACKGROUND: Facial skin rejuvenation is a highly sought after procedure. Different materials, energy‐based devices and techniques have been shown to offer good results in facial rejuvenation. AIMS: The aim of this study was to evaluate the macroscopic and histological and immunohistochemical changes in facial skin treated with a combined laser therapy. PATIENTS/METHODS: Fourteen patients aged from 38 to 59 years were included in the study. Two different wavelengths (2940 and 1064 nm) were used in this four‐step procedure. RESULTS: Significant improvement according to classification for age‐related changes in all areas of the face was achieved. There were also significant structural changes in the epidermis and dermis, confirmed with histology and immunohistochemistry. CONCLUSION: The dual‐wavelength protocol has been found to provide excellent results for facial rejuvenation.