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Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand

The interaction between the T‐lymphocyte costimulatory molecule ICOS and its ligand (ICOS‐L) is needed for efficient immune responses, but expression levels are tightly controlled, as altered expression of ICOS or ICOS‐L may lead to immunodeficiency, or favor autoimmune diseases and tumor growth. Us...

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Detalles Bibliográficos
Autores principales:	Aragoneses‐Fenoll, Laura, Montes‐Casado, María, Ojeda, Gloria, García‐Paredes, Lucía, Arimura, Yutaka, Yagi, Junji, Dianzani, Umberto, Portolés, Pilar, Rojo, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Receptors, Signal Transduction, and Genes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597029/ https://www.ncbi.nlm.nih.gov/pubmed/33527556 http://dx.doi.org/10.1002/JLB.2A0220-127R

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