Use of Mixture Dosing and Nonlinear Mixed Effect Modeling of Eight Environmental Contaminants in Rabbits to Improve Extrapolation Value of Toxicokinetic Data

BACKGROUND: Although in vivo studies of internal exposure to hazardous substances have been carried out for many years, there is room for progress to improve their informative value while adhering to the four R’s: replacement, reduction, refinement, and responsibility rule. OBJECTIVES: The objective...

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Detalles Bibliográficos
Autores principales: Gayrard, Véronique, Moreau, Jessika, Picard-Hagen, Nicole, Helies, Virginie, Marchand, Philippe, Antignac, Jean-Philippe, Toutain, Pierre-Louis, Leandri, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597046/
https://www.ncbi.nlm.nih.gov/pubmed/34786950
http://dx.doi.org/10.1289/EHP8957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597046/
https://www.ncbi.nlm.nih.gov/pubmed/34786950
http://dx.doi.org/10.1289/EHP8957

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