Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One‐Pot Synthesis of the 1,3‐Diamino‐2‐ol‐Scaffold Containing Three Continuous Stereocenters

A highly diastereoselective one‐pot synthesis of the 1,3‐diamino‐2‐alcohol unit bearing three continuous stereocenters is described. This method utilizes 2‐oxyenamides as a novel type of building block for the rapid assembly of the 1,3‐diamine scaffold containing an additional stereogenic oxygen fun...

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Detalles Bibliográficos
Autores principales: Krieg, Sara‐Cathrin, Grimmer, Jennifer, Kramer, Philipp, Bolte, Michael, Kelm, Harald, Manolikakes, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597051/
https://www.ncbi.nlm.nih.gov/pubmed/34463410
http://dx.doi.org/10.1002/anie.202109752
Descripción
Sumario:A highly diastereoselective one‐pot synthesis of the 1,3‐diamino‐2‐alcohol unit bearing three continuous stereocenters is described. This method utilizes 2‐oxyenamides as a novel type of building block for the rapid assembly of the 1,3‐diamine scaffold containing an additional stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)‐oxyenamides is reported as well.

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