Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome‐wide association study in over 12,000 non‐demented participants

INTRODUCTION: There is increasing interest in plasma amyloid beta (Aβ) as an endophenotype of Alzheimer's disease (AD). Identifying the genetic determinants of plasma Aβ levels may elucidate important biological processes that determine plasma Aβ measures. METHODS: We included 12,369 non‐dement...

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Detalles Bibliográficos
Autores principales: Damotte, Vincent, van der Lee, Sven J., Chouraki, Vincent, Grenier‐Boley, Benjamin, Simino, Jeannette, Adams, Hieab, Tosto, Giuseppe, White, Charles, Terzikhan, Natalie, Cruchaga, Carlos, Knol, Maria J., Li, Shuo, Schraen, Susanna, Grove, Megan L., Satizabal, Claudia, Amin, Najaf, Berr, Claudine, Younkin, Steven, Gottesman, Rebecca F., Buée, Luc, Beiser, Alexa, Knopman, David S., Uitterlinden, Andre, DeCarli, Charles, Bressler, Jan, DeStefano, Anita, Dartigues, Jean‐François, Yang, Qiong, Boerwinkle, Eric, Tzourio, Christophe, Fornage, Myriam, Ikram, M. Arfan, Amouyel, Philippe, de Jager, Phil, Reitz, Christiane, Mosley, Thomas H., Lambert, Jean‐Charles, Seshadri, Sudha, van Duijn, Cornelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597077/
https://www.ncbi.nlm.nih.gov/pubmed/34002480
http://dx.doi.org/10.1002/alz.12333

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