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Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations

BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long‐term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to i...

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Autores principales: Hamers, Pauline C. M., Savas, Mesut, van Rossum, Elisabeth F. C., de Rijke, Yolanda B., Bindels, Patrick J. E., Festen, Dederieke A. M., Hermans, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597165/
https://www.ncbi.nlm.nih.gov/pubmed/34047425
http://dx.doi.org/10.1111/jar.12899
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author Hamers, Pauline C. M.
Savas, Mesut
van Rossum, Elisabeth F. C.
de Rijke, Yolanda B.
Bindels, Patrick J. E.
Festen, Dederieke A. M.
Hermans, Heidi
author_facet Hamers, Pauline C. M.
Savas, Mesut
van Rossum, Elisabeth F. C.
de Rijke, Yolanda B.
Bindels, Patrick J. E.
Festen, Dederieke A. M.
Hermans, Heidi
author_sort Hamers, Pauline C. M.
collection PubMed
description BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long‐term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids. METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post‐BLT (10.000 and 300 lux). Liquid chromatography–tandem mass spectrometry was used to measure hair glucocorticoids. RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post‐intervention HairE levels were significantly increased ([95% CI: 11.2–17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0–18.3 pg/mg], p = .020). CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.
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spelling pubmed-85971652021-11-22 Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations Hamers, Pauline C. M. Savas, Mesut van Rossum, Elisabeth F. C. de Rijke, Yolanda B. Bindels, Patrick J. E. Festen, Dederieke A. M. Hermans, Heidi J Appl Res Intellect Disabil Original Articles BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long‐term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids. METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post‐BLT (10.000 and 300 lux). Liquid chromatography–tandem mass spectrometry was used to measure hair glucocorticoids. RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post‐intervention HairE levels were significantly increased ([95% CI: 11.2–17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0–18.3 pg/mg], p = .020). CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities. John Wiley and Sons Inc. 2021-05-28 2021-11 /pmc/articles/PMC8597165/ /pubmed/34047425 http://dx.doi.org/10.1111/jar.12899 Text en © 2021 The Authors. Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Hamers, Pauline C. M.
Savas, Mesut
van Rossum, Elisabeth F. C.
de Rijke, Yolanda B.
Bindels, Patrick J. E.
Festen, Dederieke A. M.
Hermans, Heidi
Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title_full Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title_fullStr Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title_full_unstemmed Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title_short Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
title_sort hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: first explorations
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597165/
https://www.ncbi.nlm.nih.gov/pubmed/34047425
http://dx.doi.org/10.1111/jar.12899
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