Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome

The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and m...

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Detalles Bibliográficos
Autores principales: Shchukina, Irina, Bagaitkar, Juhi, Shpynov, Oleg, Loginicheva, Ekaterina, Porter, Sofia, Mogilenko, Denis A., Wolin, Erica, Collins, Patrick, Demidov, German, Artomov, Mykyta, Zaitsev, Konstantin, Sidorov, Sviatoslav, Camell, Christina, Bambouskova, Monika, Arthur, Laura, Swain, Amanda, Panteleeva, Alexandra, Dievskii, Aleksei, Kurbatsky, Evgeny, Tsurinov, Petr, Chernyatchik, Roman, Dixit, Vishwa Deep, Jovanovic, Marko, Stewart, Sheila A., Daly, Mark J., Dmitriev, Sergey, Oltz, Eugene M., Artyomov, Maxim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597198/
https://www.ncbi.nlm.nih.gov/pubmed/34796338
http://dx.doi.org/10.1038/s43587-020-00002-6

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