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Engineered microbial consortia: strategies and applications
Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these lim...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597270/ https://www.ncbi.nlm.nih.gov/pubmed/34784924 http://dx.doi.org/10.1186/s12934-021-01699-9 |
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author | Duncker, Katherine E. Holmes, Zachary A. You, Lingchong |
author_facet | Duncker, Katherine E. Holmes, Zachary A. You, Lingchong |
author_sort | Duncker, Katherine E. |
collection | PubMed |
description | Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia. |
format | Online Article Text |
id | pubmed-8597270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85972702021-11-17 Engineered microbial consortia: strategies and applications Duncker, Katherine E. Holmes, Zachary A. You, Lingchong Microb Cell Fact Review Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia. BioMed Central 2021-11-16 /pmc/articles/PMC8597270/ /pubmed/34784924 http://dx.doi.org/10.1186/s12934-021-01699-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Duncker, Katherine E. Holmes, Zachary A. You, Lingchong Engineered microbial consortia: strategies and applications |
title | Engineered microbial consortia: strategies and applications |
title_full | Engineered microbial consortia: strategies and applications |
title_fullStr | Engineered microbial consortia: strategies and applications |
title_full_unstemmed | Engineered microbial consortia: strategies and applications |
title_short | Engineered microbial consortia: strategies and applications |
title_sort | engineered microbial consortia: strategies and applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597270/ https://www.ncbi.nlm.nih.gov/pubmed/34784924 http://dx.doi.org/10.1186/s12934-021-01699-9 |
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