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Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model

Aim: The aim of our study was to assess the therapeutic effects of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) in an animal knee lesion complex associating a large osteochondral defect and meniscal defect resulted from partial meniscectomy, a clinical situation that occurs...

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Autores principales: Lăzărescu, Adrian Emil, Văduva, Adrian Ovidiu, Hogea, Gheorghe Bogdan, Croicu, Cristian, Pătraşcu Jr, Jenel Marian, Petrescu, Pompiliu Horaţiu, Andor, Bogdan Corneliu, Muntean, Mirela Danina, Pătraşcu, Jenel Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597375/
https://www.ncbi.nlm.nih.gov/pubmed/34609430
http://dx.doi.org/10.47162/RJME.62.1.27
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author Lăzărescu, Adrian Emil
Văduva, Adrian Ovidiu
Hogea, Gheorghe Bogdan
Croicu, Cristian
Pătraşcu Jr, Jenel Marian
Petrescu, Pompiliu Horaţiu
Andor, Bogdan Corneliu
Muntean, Mirela Danina
Pătraşcu, Jenel Marian
author_facet Lăzărescu, Adrian Emil
Văduva, Adrian Ovidiu
Hogea, Gheorghe Bogdan
Croicu, Cristian
Pătraşcu Jr, Jenel Marian
Petrescu, Pompiliu Horaţiu
Andor, Bogdan Corneliu
Muntean, Mirela Danina
Pătraşcu, Jenel Marian
author_sort Lăzărescu, Adrian Emil
collection PubMed
description Aim: The aim of our study was to assess the therapeutic effects of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) in an animal knee lesion complex associating a large osteochondral defect and meniscal defect resulted from partial meniscectomy, a clinical situation that occurs quite often in orthopedic practice. Materials and Methods: Twenty-one male rabbits were included in the study, and all underwent initial surgery on the right knee to create the osteochondral defect on the internal femoral condyle, and remove the anterior horn of the internal meniscus, simulating a clinical situation. Rabbits were separated in three study groups: control, PRP group, in which three PRP injections were administered, and BMAC group, in which one single BMAC injection was administered. At the end of the six months follow-up period, knees were harvested and further analyzed using confocal microscopy and three-dimensional (3D) reconstruction of the articular surface. Results: Therapeutic groups had better results concerning articular surface remodeling and joint degeneration indicators in comparison to trauma group. Conclusions: Our results suggest that using post-operative regenerative therapies does improve final results concerning surface contact remodeling that was investigated using confocal microscopy and should be considered a valid treatment adjuvant in managing patients with this type of lesion complex, as it improves global joint outcome.
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spelling pubmed-85973752021-12-01 Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model Lăzărescu, Adrian Emil Văduva, Adrian Ovidiu Hogea, Gheorghe Bogdan Croicu, Cristian Pătraşcu Jr, Jenel Marian Petrescu, Pompiliu Horaţiu Andor, Bogdan Corneliu Muntean, Mirela Danina Pătraşcu, Jenel Marian Rom J Morphol Embryol Original Paper Aim: The aim of our study was to assess the therapeutic effects of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) in an animal knee lesion complex associating a large osteochondral defect and meniscal defect resulted from partial meniscectomy, a clinical situation that occurs quite often in orthopedic practice. Materials and Methods: Twenty-one male rabbits were included in the study, and all underwent initial surgery on the right knee to create the osteochondral defect on the internal femoral condyle, and remove the anterior horn of the internal meniscus, simulating a clinical situation. Rabbits were separated in three study groups: control, PRP group, in which three PRP injections were administered, and BMAC group, in which one single BMAC injection was administered. At the end of the six months follow-up period, knees were harvested and further analyzed using confocal microscopy and three-dimensional (3D) reconstruction of the articular surface. Results: Therapeutic groups had better results concerning articular surface remodeling and joint degeneration indicators in comparison to trauma group. Conclusions: Our results suggest that using post-operative regenerative therapies does improve final results concerning surface contact remodeling that was investigated using confocal microscopy and should be considered a valid treatment adjuvant in managing patients with this type of lesion complex, as it improves global joint outcome. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2021 2021-10-01 /pmc/articles/PMC8597375/ /pubmed/34609430 http://dx.doi.org/10.47162/RJME.62.1.27 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Lăzărescu, Adrian Emil
Văduva, Adrian Ovidiu
Hogea, Gheorghe Bogdan
Croicu, Cristian
Pătraşcu Jr, Jenel Marian
Petrescu, Pompiliu Horaţiu
Andor, Bogdan Corneliu
Muntean, Mirela Danina
Pătraşcu, Jenel Marian
Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title_full Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title_fullStr Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title_full_unstemmed Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title_short Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
title_sort comparing prp and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597375/
https://www.ncbi.nlm.nih.gov/pubmed/34609430
http://dx.doi.org/10.47162/RJME.62.1.27
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