4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3C(pro)

The fatal pathogen enterovirus 71 (EV71) is a major cause of hand-foot-and-mouth disease (HFMD), which leads to serious neurological syndromes. While there are no effective clinical agents available for EV71 treatment thus far, EV71 3C protease (3C(pro)), a cysteine protease encoded by the virus, ha...

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Detalles Bibliográficos
Autores principales: Xu, Binghong, Liu, Meijun, Ma, Sen, Ma, Yuying, Liu, Si, Shang, Luqing, Zhu, Cheng, Ye, Sheng, Wang, Yaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597634/
https://www.ncbi.nlm.nih.gov/pubmed/34787443
http://dx.doi.org/10.1128/Spectrum.01025-21

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