Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient

Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia. We discuss a case of a two-year-old male who developed severe persistent methemoglobinemia treated with multiple doses of methylene blue (MB), multidose activated charcoal, and vitamin C. Methylene blue infusion...

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Detalles Bibliográficos
Autores principales: Alyahya, Bader, Alalshaikh, Abdulaziz, Sabbahi, Ghofran, Alnowiser, Mosaed, Al-Mohawes, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Emergency Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597667/
https://www.ncbi.nlm.nih.gov/pubmed/34804706
http://dx.doi.org/10.7759/cureus.18853
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author Alyahya, Bader
Alalshaikh, Abdulaziz
Sabbahi, Ghofran
Alnowiser, Mosaed
Al-Mohawes, Mohammed
author_facet Alyahya, Bader
Alalshaikh, Abdulaziz
Sabbahi, Ghofran
Alnowiser, Mosaed
Al-Mohawes, Mohammed
author_sort Alyahya, Bader
collection PubMed
description Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia. We discuss a case of a two-year-old male who developed severe persistent methemoglobinemia treated with multiple doses of methylene blue (MB), multidose activated charcoal, and vitamin C. Methylene blue infusion (rather than bolus dosing) aided in controlling this patient’s methemoglobin (MetHb) levels and symptoms and may reduce the total needed dose.
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spelling pubmed-85976672021-11-20 Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient Alyahya, Bader Alalshaikh, Abdulaziz Sabbahi, Ghofran Alnowiser, Mosaed Al-Mohawes, Mohammed Cureus Emergency Medicine Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia. We discuss a case of a two-year-old male who developed severe persistent methemoglobinemia treated with multiple doses of methylene blue (MB), multidose activated charcoal, and vitamin C. Methylene blue infusion (rather than bolus dosing) aided in controlling this patient’s methemoglobin (MetHb) levels and symptoms and may reduce the total needed dose. Cureus 2021-10-18 /pmc/articles/PMC8597667/ /pubmed/34804706 http://dx.doi.org/10.7759/cureus.18853 Text en Copyright © 2021, Alyahya et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Alyahya, Bader
Alalshaikh, Abdulaziz
Sabbahi, Ghofran
Alnowiser, Mosaed
Al-Mohawes, Mohammed
Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title_full Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title_fullStr Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title_full_unstemmed Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title_short Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient
title_sort methylene blue infusion to treat severe dapsone-induced methemoglobinemia in a pediatric patient
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597667/
https://www.ncbi.nlm.nih.gov/pubmed/34804706
http://dx.doi.org/10.7759/cureus.18853
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