A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus

Fluoroquinolones—the only clinically used DNA gyrase inhibitors—are effective against tuberculosis (TB) but are in limited clinical use for nontuberculous mycobacteria (NTM) lung infections due to intrinsic drug resistance. We sought to test alternative DNA gyrase inhibitors for anti-NTM activity. M...

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Detalles Bibliográficos
Autores principales: Ganapathy, Uday S., del Río, Rubén González, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D., Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597734/
https://www.ncbi.nlm.nih.gov/pubmed/34606340
http://dx.doi.org/10.1128/AAC.01514-21

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